Serpina1a

  • Official Full Name

    serine (or cysteine) peptidase inhibitor, clade A, member 1A

  • Overview

    Alpha 1-Antitrypsin is a 52 kDA serine protease inhibitor (serpin) in blood, which protects tissue from enzymes from inflammatory cells, especially elastase. In certain acute phase inflammatory reactions, A1AT is elevated in order to limit the damage caused by activated neutrophil granulocytes and their enzyme elastase. Disorders of A1AT include A1AT deficiency, a hereditary disorder that can lead to severe tissue breakdown during inflammation. This may result in pulmonary emphysema and liver cirrhosis, in severe cases. Genetic variants of A1AT do occur.

  • Synonyms

    Aat-2;Aat2;Dom1;PI1;Spi1-1;Spi1-3;AAT;alpha-1 protease inhibitor 1;alpha-1-antiproteinase;alpha-1-antitrypsin 1-1;alpha-1-antitrypsin 2;serine (or cysteine) proteinase inhibitor, clade A, member 1a;serine protease inhibitor 1-1;serine protease inhibitor A1a;serpin A1a

Recombinant Proteins

  • Mouse
  • Mammalian cells
  • E.coli
  • HEK293
  • Human Cell
  • His
  • Non
  • Fc
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
Serpina1a-304M Active Recombinant Mouse Serpina1a, His-tagged Mammalian cells Mouse His 25-413 a.a.
Serpina1a-1816M Recombinant Mouse Serpina1a protein, His-tagged E.coli Mouse His Glu25~Lys413
Serpina1a-471M Active Recombinant Mouse Serpina1a protein HEK293 Mouse Non Met1-Lys413
Serpina1a-472M Active Recombinant Mouse Serpina1a protein(Met1-Lys413), hFc-tagged HEK293 Mouse Fc Met1-Lys413
Serpina1a-473M Recombinant Mouse Serpina1a, His-tagged Human Cell Mouse His Met1-Lys413
SERPINA1A-001MCL Recombinant Mouse SERPINA1A cell lysate Human Cell Mouse Non
SERPINA1A-002MCL Recombinant Mouse SERPINA1A cell lysate Human Cell Mouse Non
SERPINA1A-003MCL Recombinant Mouse SERPINA1A cell lysate Human Cell Mouse Non
Serpina1a-8039M Recombinant Mouse Serpina1a Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
Serpina1a-8039M-B Recombinant Mouse Serpina1a Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    Serpina1a involved in several pathways and played different roles in them. We selected most pathways Serpina1a participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with Serpina1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades F7,SERPINA5,C1R,CR1L,C1RA,CFH,SERPINE1,CFD,SERPINA1D,Hc

    Protein Function

    Serpina1a has several biochemical functions, for example, endopeptidase inhibitor activity,glycoprotein binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Serpina1a itself. We selected most functions Serpina1a had, and list some proteins which have the same functions with Serpina1a. You can find most of the proteins on our site.

    Function Related Protein
    protein binding IL1A,EIF4E,TRAM1,RORB,RCHY1,PALM,BSX,ATXN1L,ABCE1,BCKDHA
    peptidase inhibitor activity WFDC6B,KAL1B,SPINT4,SERPINB11,MUG2,SERPINB1C,ITIH3,SERPINA3M,WFDC6A,EPPIN
    serine-type endopeptidase inhibitor activity PCSK1NL,SERPINB3C,SERPINB11,SERPING1,CCNH,SERPINA1E,SERPINA1,SPINLW1,RECK,APLP2
    glycoprotein binding FLNA,SERPINA1,PTBP3,AZGP1,CALR,VLDLR,CD4,ERBB2,APOH,SERPINA1E
    identical protein binding C1QL4,ECI1,ITGA2B,MRAP2,MUL1,GLUL,RILPL2,PCM1,GRIK5,RNF4
    protease binding C10orf2,INS1,A2M,FLOT1,TIMP4,Serpina1b,BCL10,Serpina1c,SERPINA1,SERPINB9
    endopeptidase inhibitor activity SPINK2,SPINT2,C4A,WFDC2,ITIH2,PZP,CST7,TFPI,Serpina1c,A1i3

    Interacting Protein

    Serpina1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Serpina1a here. Most of them are supplied by our site. Hope this information will be useful for your research of Serpina1a.

    Resources

    References

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All Serpina1a Products

    Required fields are marked with *

    My Review for All Serpina1a Products

    Required fields are marked with *