SYNGAP1
-
Official Full Name
synaptic Ras GTPase activating protein 1 -
Overview
The protein encoded by this gene is a major component of the postsynaptic density (PSD), a group of proteins found associated with NMDA receptors at synapses. The encoded protein is phosphorylated by calmodulin-dependent protein kinase II and dephosphorylated by NMDA receptor activation. Defects in this gene are a cause of mental retardation autosomal dominant type 5 (MRD5). [provided by RefSeq, Dec 2009] -
Synonyms
SYNGAP1;synaptic Ras GTPase activating protein 1;MRD5;RASA1;RASA5;SYNGAP;ras/Rap GTPase-activating protein SynGAP;neuronal RasGAP;Ras GTPase-activating protein SynGAP;synaptic Ras GTPase-activating protein 1;synaptic Ras GTPase activating protein, 135kDa;synaptic Ras GTPase activating protein 1 homolog
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SYNGAP1-2648H | Recombinant Human SYNGAP1 Protein (1161-1343 aa), His-tagged | E.coli | Human | His | 1161-1343 aa |
|
| SYNGAP1-2745H | Recombinant Human SYNGAP1 Protein, His-tagged | E.coli | Human | His | Gly443-Asn635 |
|
Involved Pathway
SYNGAP1 involved in several pathways and played different roles in them. We selected most pathways SYNGAP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SYNGAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SYNGAP1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by SYNGAP1 itself. We selected most functions SYNGAP1 had, and list some proteins which have the same functions with SYNGAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
SYNGAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYNGAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYNGAP1.
Resources
Related Services
Related Products
References
- Lee, YS; Ehninger, D; et al. Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome. NATURE NEUROSCIENCE 17:1736-1743(2014).
- Stricker, R; Reiser, G; et al. Functions of the neuron-specific protein ADAP1 (centaurin-alpha 1) in neuronal differentiation and neurodegenerative diseases, with an overview of structural and biochemical properties of ADAP1. BIOLOGICAL CHEMISTRY 395:1321-1340(2014).
