SUMO4

  • Official Full Name

    SMT3 suppressor of mif two 3 homolog 4

  • Overview

    This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.

  • Synonyms

    SUMO4;SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae);SMT3 suppressor of mif two 3 homolog 4 (yeast) , SMT3H4;small ubiquitin-related modifier 4;dJ281H8.4;SMT3 suppressor of mif two 3 homolog 2;small ubiquitin-like modifier 4 protein;IDDM5
Cat.# Product name Source (Host) Species Tag Protein Length Price
SUMO4-1723HCL Recombinant Human SUMO4 cell lysate Human Non
SUMO4-3015H Recombinant Human SUMO4 Protein, His-tagged E.coli Human His
SUMO4-4514H Recombinant Human SUMO4 protein, GST-tagged E.coli Human GST 1-95aa

    Involved Pathway

    SUMO4 involved in several pathways and played different roles in them. We selected most pathways SUMO4 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUMO4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA transport EIF4A1B,CYFIP2,EIF3B,TPR,NUP155,PABPC3,UBE2IA,POP1,SENP2,RPP30

    Protein Function

    SUMO4 has several biochemical functions, for example, SUMO transferase activity,protein tag. Some of the functions are cooperated with other proteins, some of the functions could acted by SUMO4 itself. We selected most functions SUMO4 had, and list some proteins which have the same functions with SUMO4. You can find most of the proteins on our site.

    Function Related Protein
    protein tag SUMO2,NFATC2IP,SUMO3A,SUMO3,SUMO2B,SUMO3B,SUMO1,RNF41,ISG15,UBL5
    SUMO transferase activity UBE2IB,SUMO1,NSMCE2,MUL1,PIAS4,TOPORS,UBE2IA,SUMO3,UBE2I,PIAS3

    Interacting Protein

    SUMO4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUMO4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUMO4.

    SUMO4 Related Signal Pathway

    Resources

    Research Area

    Ubiquitin-like Modifiers (UBLs) and Regulators
    Post-translational Modification of NFkB/IkB

    References

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