SULF2
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Official Full Name
sulfatase 2 -
Overview
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and;are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate;groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for;signaling molecules (Dai et al., 2005 (PubMed 16192265)). -
Synonyms
SULF2;sulfatase 2;extracellular sulfatase Sulf-2;HSULF 2;KIAA1247;SULF 2;Extracellular sulfatase Sulf 2;HSulf-2;HSulf2;SULF2_HUMAN
Recombinant Proteins
- Human
- Mouse
- Flavobacterium heparinum
- E.coli
- Mammalian Cell
- HEK293
- GST
- His&GST
- His
- Non
- His&Fc&Avi
Involved Pathway
SULF2 involved in several pathways and played different roles in them. We selected most pathways SULF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SULF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SULF2 has several biochemical functions, for example, N-acetylglucosamine-6-sulfatase activity,arylsulfatase activity,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SULF2 itself. We selected most functions SULF2 had, and list some proteins which have the same functions with SULF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N-acetylglucosamine-6-sulfatase activity | GNSB,GNS,SULF1,GNSA |
| calcium ion binding | STIM1,DSG4,NOX5,MMP10,EGFL6,PCDH8,CALB2B,S100B,MMP12,NKD2B |
| arylsulfatase activity | ARSH,ARSF,ARSI,ARSB,ARSE,SULF1,ARSG,ARSJ,ARSK,ARSA |
Interacting Protein
SULF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SULF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SULF2.
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References
- Singer, MS; Phillips, JJ; et al. SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis. CLINICA CHIMICA ACTA 440:72-78(2015).
- Joy, MT; Vrbova, G; et al. Sulf1 and Sulf2 expression in the nervous system and its role in limiting neurite outgrowth in vitro. EXPERIMENTAL NEUROLOGY 263:150-160(2015).
- Alhasan, AA; Spielhofer, J; et al. Role of 6-O-Sulfated Heparan Sulfate in Chronic Renal Fibrosis. JOURNAL OF BIOLOGICAL CHEMISTRY 289:20295-20306(2014).
- Lui, NS; van Zante, A; et al. SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study. BMJ OPEN 2:-(2012).
