STK4
-
Official Full Name
serine/threonine kinase 4 -
Overview
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and its possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008] -
Synonyms
STK4;serine/threonine kinase 4;KRS2;MST1;YSK3;TIIAC;serine/threonine-protein kinase 4;MST-1;STE20-like kinase MST1;mammalian sterile 20-like 1;kinase responsive to stress 2;mammalian STE20-like protein kinase 1;serine/threonine-protein kinase Krs-2;dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Mouse
- Insect Cell
- E.coli
- Mammalian Cell
- Sf9 Insect Cell
- Mammalian cells
- HEK293T
- HEK293
- Insect (sf21)
- His
- GST
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
STK4 involved in several pathways and played different roles in them. We selected most pathways STK4 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | PLA2G1B,PLA2G4D,AKT1,RASSF5,VEGFC,NF1,Pdgfa&Pdgfb,PIK3CA,PDGFRB,PLA2G6 |
| FoxO signaling pathway | PIK3R2,IGF1R,SOS1,MAPK14A,PIK3CB,FASLG,AKT2L,PIK3CA,STK11,CCND2A |
| Pathways in cancer | NTRK1,FGF6,RXRB,PLD1,EP300,FAS,BRAF,PTCH2,F2RL3,CCND1 |
| MAPK signaling pathway | MECOM,FGF20,TGFBR2,PRKACB,TGFB1A,PDGFRB,MAPK11,CASP3B,RAP1B,RAC1A |
| Non-small cell lung cancer | CASP9,PLCG2,ERBB2,HRAS,KRAS,PRKCG,BRAF,TP53,PIK3R2,AKT1 |
Protein Function
STK4 has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STK4 itself. We selected most functions STK4 had, and list some proteins which have the same functions with STK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SDPR,NRL,IGF2,KRTAP19-7,XAGE2,TBK1,C2orf65,PRC1,ARHGEF38,NR4A2 |
| MAP kinase kinase kinase activity | MAP3K5,MAP3K2,MOS,EGFR,RAF1,ZAK,BRAF,MAP3K4,TAOK1,MAP3K1 |
| protein dimerization activity | ARNTL,MESPBB,HER15.1,NCOA2,ERBB2,MXD1,SCXB,TAL2,HPS4,MESPAA |
| protein kinase activity | MAP2K1,MAP3K11,MAP3K10,STK24A,IRAK1,FYNA,CCL3,HIPK3A,KDRL,LTK |
| magnesium ion binding | ABL2,TSSK4,ILVBL,ATP9A,IDH3G,NUDT3,RNASEH1,PKLR,ENO4,RPS6KAL |
| protein serine/threonine kinase activity | ACVR1BA,LMTK2,IRAK2,BMPR1A,SRPK1A,TSSK1,SGK2A,ULK1A,CDK15,ACVRL1 |
| transcription factor binding | ATG7,TBP,NFKB1,NKX3,MED25,SOX17,SRF,LMO4,IFI16,HDAC11 |
| protein serine/threonine kinase activator activity | SPRY2,CALM1,MAP2K1,STRADA,CDK5R1,CALM3,ALS2,IGF2,STK3,CALM2 |
| ATP binding | EIF2AK1,MYO5B,EPHA3,NMRK1,TTLL3,UCKL1A,CDK7,PRPF4BA,FARSB,SIK2A |
Interacting Protein
STK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of STK4.
SAV1;RASSF2
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