STIM1
-
Official Full Name
stromal interaction molecule 1 -
Overview
Ca2+ is a key second messenger in many intracellular signaling pathways. Ca2+ signals control many cellular functions ranging from short-term responses such as contraction and secretion to longer-term regulation of cell growth and proliferation. Stromal i -
Synonyms
STIM1;stromal interaction molecule 1;D11S4896E;GOK;STIM1L
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Rat
- HEK293
- E.coli
- Mammalian Cell
- Human
- Human Cell
- E.coli expression system
- Mammalian cells
- HEK293T
- His
- CaM
- Non
- His&T7
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
STIM1 involved in several pathways and played different roles in them. We selected most pathways STIM1 participated on our site, such as Calcium signaling pathway,Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with STIM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | PTGER1A,CD38,GNAS,ADRB2A,DRD5,GNA11A,TNNC1B,GRIN2A,ADORA2AA,PHKG1 |
| Platelet activation | AKT2,PIK3CA,MAPK12,SNAP23,MAPK3,PTGS1,ARHGEF12,P2RY1,FYN,GP1BA |
Protein Function
STIM1 has several biochemical functions, for example, calcium channel regulator activity,calcium ion binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STIM1 itself. We selected most functions STIM1 had, and list some proteins which have the same functions with STIM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium channel regulator activity | GNB2,NRXN1,TSPAN13B,PRKCB,GRM2,TSPAN13,Crisp4,NRXN3,CACNA2D4,PRKG1 |
| microtubule plus-end binding | KIF2C,DST,APC,CLIP2,CLASP1,KIF18A,CLIP1,MAPRE1,CLASP1A |
| identical protein binding | SOD1,ATXN10,PPP5C,CLDN1,SNX1,SIAH1,NISCH,CSNK2B,DES,CLDN3 |
| protein binding | EXOSC7,GATAD2A,DIS3L,COASY,RND1,PPFIA2,S1PR3,ACAA2,GSTO2,DLGAP1 |
| protease binding | SERPINB4,NFRKB,CNTNAP2,FADD,TNFAIP3,SRI,CCDC71L,SEMG2,TIMP3,ITGB1 |
| calcium ion binding | CAPSL,PCDH2G2,CIB4,MMP16,ZFP652,SLC25A24,SPOCK2,BGLAP-RS1,ATP2A2,CACNA1SA |
Interacting Protein
STIM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STIM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of STIM1.
ORAI1
Resources
Related Services
Related Products
References
- Saliba, Y; Keck, M; et al. Emergence of Orai3 activity during cardiac hypertrophy. CARDIOVASCULAR RESEARCH 105:248-259(2015).
- Gaida, K; Salimi-Moosavi, H; et al. Inhibition of CRAC with a human anti-ORAI1 monoclonal antibody inhibits T-cell-derived cytokine production but fails to inhibit a T-cell-dependent antibody response in the cynomolgus monkey. JOURNAL OF IMMUNOTOXICOLOGY 12:164-173(2015).
