STEAP1
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Official Full Name
six transmembrane epithelial antigen of the prostate 1 -
Overview
This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. -
Synonyms
STEAP1;six transmembrane epithelial antigen of the prostate 1;six transmembrane epithelial antigen of the prostate , STEAP;metalloreductase STEAP1;PRSS24;six-transmembrane epithelial antigen of prostate 1;STEAP;MGC19484
Recombinant Proteins
- Human
- Mus musculus
- Sus scrofa (Pig)
- Mouse
- E.coli
- HEK293
- E.coli expression system
- In vitro E. coli expression system
- HEK293T
- Mammalian cells
- His
- Non
- His&Fc&Avi
- His&SUMO
- Myc&DDK
- Flag
- GST
Involved Pathway
STEAP1 involved in several pathways and played different roles in them. We selected most pathways STEAP1 participated on our site, such as Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with STEAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mineral absorption | ATP1A3,HMOX1,SLC30A1,CLCN2,HEPH,ATP1A1,SLC5A1,SLC11A2,SLC31A1,SLC9A3 |
Protein Function
STEAP1 has several biochemical functions, for example, channel activity,NOT cupric reductase activity,NOT ferric-chelate reductase (NADPH) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by STEAP1 itself. We selected most functions STEAP1 had, and list some proteins which have the same functions with STEAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transporter activity | AP2M1,FABP1B.1,FABP5,LCN12,RBP7B,MUP17,ATP5B,SLC22A1,HIAT1,SLC5A3A |
| channel activity | BAXA,TRPA1,BAX,CHRNB1,PANX1B,BCL2,MAL,P2RX6,PANX2,PANX1A |
| metal ion binding | ZFP639,NRXN1A,SDHD,HDHD1A,CYP46A1.4,UNK,MDP1,ZC4H2,TRIM35-34,ZSCAN4F |
Interacting Protein
STEAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STEAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of STEAP1.
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