STAR
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Official Full Name
steroidogenic acute regulatory protein -
Overview
The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the;conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by;mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane.;Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A;pseudogene of this gene is located on chromosome 13. -
Synonyms
STAR;steroidogenic acute regulatory protein;steroidogenic acute regulator;steroidogenic acute regulatory protein, mitochondrial;StAR related lipid transfer (START) domain containing 1;STARD1;mitochondrial;Cholesterol trafficker;Luteinizing hormone induced protein;Luteinizing hormone-induced protein;Mitochondrial steroid acute regulatory protein;STAR_HUMAN;START domain containing protein 1;START domain-containing protein 1;Steroidogenic acute regulatory protein mitochondrial;OTTHUMP00000225718;OTTHUMP00000225719;OTTHUMP00000225878;START domain containing 1;steroid acute regulatory protein;START domain-containing protein
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- E.coli
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- His&GST
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
- GST
Involved Pathway
STAR involved in several pathways and played different roles in them. We selected most pathways STAR participated on our site, such as Ovarian steroidogenesis,Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aldosterone synthesis and secretion | HSD3B2,PRKD3,CYP11A1,ITPR1,ATF2,CAMK2A,NPR1,AKR1C1,GNAS,LIPE |
| Ovarian steroidogenesis | PTGS2,HSD3B2,HSD3B5,PLA2G4A,GDF9,GNAS,IGF1R,PRKACA,FSHB,SCARB1 |
Protein Function
STAR has several biochemical functions, for example, cholesterol binding,cholesterol transporter activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAR itself. We selected most functions STAR had, and list some proteins which have the same functions with STAR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cholesterol transporter activity | APOB,APOA4A,ABCG4B,ABCA1,APOA1A,APOA4,ABCA13,ABCA1B,ABCA4A,APOA4B.1 |
| cholesterol binding | ERLIN2,NPC2,APOA4A,ANXA6,OSBPL3,APOA4B.1,OSBPL7,ERLIN1,APOA1A,APOA1 |
| protein binding | IMP3,FAM46B,UBA1,DRAXIN,MUSK,TRIM38,ILK,KIAA1737,TWSG1,SNX10 |
Interacting Protein
STAR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAR here. Most of them are supplied by our site. Hope this information will be useful for your research of STAR.
MAGEA11;CCHCR1;FEZ1
Resources
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References
- Kahveci, MU; Ciftci, M; et al. Photoinduced in situ formation of clickable PEG hydrogels and their antibody conjugation. DESIGNED MONOMERS AND POLYMERS 18:129-136(2015).
- Accialini, P; Hernandez, SF; et al. A link between Notch and progesterone maintains the functionality of the rat corpus luteum. REPRODUCTION 149:1-10(2015).
