ST3GAL5
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Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 5 -
Overview
Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ST3GAL5;ST3 beta-galactoside alpha-2,3-sialyltransferase 5;sialyltransferase 9 (CMP NeuAc:lactosylceramide alpha 2,3 sialyltransferase;GM3 synthase) , SIAT9;lactosylceramide alpha-2,3-sialyltransferase;SIATGM3S;ST3GalV;3-sialyltransferase;CMP-NeuAc:lactosylceramide alpha-2;CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase;EC 2.4.99.9;Ganglioside GM3 synthase;Lactosylceramide alpha-2;Sialyltransferase 9;SIAT9;SIAT9_HUMAN;ST3GAL;ST3Gal V;GM3 synthase;alpha 2,3-sialyltransferase V;sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase;GM3 synthase);SATI
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
ST3GAL5 involved in several pathways and played different roles in them. We selected most pathways ST3GAL5 participated on our site, such as Glycosphingolipid biosynthesis - ganglio series,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ST3GAL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | GCNT1,PLCB1,HSD3B7,ASAH1A,NT5C1A,G6PDX,GLULB,SUCLG1,ALOX12B,CMPK2 |
| Glycosphingolipid biosynthesis - ganglio series | HEXB,ST3GAL2,ST6GALNAC4,GLB1,ST6GALNAC5,ST6GALNAC6,SLC33A1,ST6GALNAC3,ST8SIA1,B3GALT4 |
Protein Function
ST3GAL5 has several biochemical functions, for example, beta-galactoside (CMP) alpha-2,3-sialyltransferase activity,lactosylceramide alpha-2,3-sialyltransferase activity,neolactotetraosylceramide alpha-2,3-sialyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ST3GAL5 itself. We selected most functions ST3GAL5 had, and list some proteins which have the same functions with ST3GAL5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sialyltransferase activity | ST8SIA3,ST3GAL3B,ST6GAL2B,ST6GALNAC1.2,ST6GAL1,ST6GALNAC5B,ST8SIA1,ST3GAL3A,ST6GALNAC3,ST6GALNAC6 |
| lactosylceramide alpha-2,3-sialyltransferase activity | ST3GAL5L |
| beta-galactoside (CMP) alpha-2,3-sialyltransferase activity | ST3GAL5L,ST3GAL3A,ST3GAL2,ST3GAL3B,ST3GAL4,ST3GAL1,ST3GAL2L,ST3GAL3 |
Interacting Protein
ST3GAL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ST3GAL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ST3GAL5.
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References
- Zhang, P; Xiang, N; et al. Family-based association analysis to finemap bipolar linkage peak on chromosome 8q24 using 2,500 genotyped SNPs and 15,000 imputed SNPs. BIPOLAR DISORDERS 12:786-792(2010).
