ST3GAL1
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Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -
Overview
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. -
Synonyms
ST3GAL1;ST3 beta-galactoside alpha-2,3-sialyltransferase 1;sialyltransferase 4A (beta galactosidase alpha 2,3 sialytransferase) , SIAT4A;CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1;SIATFL;ST3Gal I;ST3GalA.1;ST3O;3-GalNAc-alpha-2;3-sialyltransferase 1;3-sialyltransferase;3-ST 1;Alpha 2;Alpha 23 ST;Alpha 23-ST;Beta galactoside alpha 23 sialyltransferase;Beta-galactoside alpha-2;beta-galactoside alpha-2,3-sialyltransferase 1;Beta-galactoside alpha-23-sialyltransferase;CMP N acetylneuraminate beta galactosamide alpha 23 sialyltransferase;CMP-N-acetylneuraminate-beta-galactosamide-alpha-2;DKFZp666E036;DKFZp779K2051;FLJ36548;Gal beta 13 GalNAc alpha 23 sialyltransferase;Gal NAc6S;Gal-beta-1;Gal-beta-13-GalNAc-alpha-23-sialyltransferase;Gal-NAc6S;MGC9183;OTTHUMP00000226912;OTTHUMP00000226913;SIA4A_HUMAN;Sialyltransferase 4A;SIAT4-A;SIAT4A;ST3GalA;ST3GalI;ST3GalIA;alpha 2,3-ST 1;Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase;sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase);sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase);sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase);ST3GalIA,1
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Chicken
- Mus musculus
- Sus scrofa (Pig)
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli expression system
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- His
- Non
- HA
- His&GFP
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ST3GAL1 involved in several pathways and played different roles in them. We selected most pathways ST3GAL1 participated on our site, such as Mucin type O-Glycan biosynthesis,Glycosaminoglycan biosynthesis - keratan sulfate,Glycosphingolipid biosynthesis - globo series, which may be useful for your reference. Also, other proteins which involved in the same pathway with ST3GAL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosphingolipid biosynthesis - globo series | FUT1,GLA,B3GALT5,B3GALNT1,GBGT1,NAGA,HEXA,HEXB,GBGT1L4,FUT9 |
| Glycosphingolipid biosynthesis - ganglio series | ST6GALNAC4,HEXA,B4GALNT1,ST8SIA1,GLB1,ST3GAL2,ST6GALNAC6,SLC33A1,B3GALT4,ST6GALNAC3 |
| Glycosaminoglycan biosynthesis - keratan sulfate | B4GALT2,CHST1,CHST4,CHST2A,B3GNT1,B4GALT1,B3GNT2,B3GNT2B,CHST6,Chst5 |
| Mucin type O-Glycan biosynthesis | POC1BL,GALNTL4,GALNT11,GALNT3,GCNT4A,GCNT4,C1GALT1C1,GALNT10,GALNT13,GALNT6 |
| Metabolic pathways | UMPS,CHPT1,IDUA,ATP5G3B,NAT2,GUK1B,RDH11,XDH,CYP2B6,PAFAH1B3 |
Protein Function
ST3GAL1 has several biochemical functions, for example, beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ST3GAL1 itself. We selected most functions ST3GAL1 had, and list some proteins which have the same functions with ST3GAL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-galactoside (CMP) alpha-2,3-sialyltransferase activity | ST3GAL3,ST3GAL2L,ST3GAL2,ST3GAL5L,ST3GAL5,ST3GAL3B,ST3GAL3A,ST3GAL4 |
Interacting Protein
ST3GAL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ST3GAL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ST3GAL1.
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