SSX3
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Official Full Name
synovial sarcoma, X breakpoint 3 -
Overview
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of chromosome translocation. Two transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
SSX3;synovial sarcoma, X breakpoint 3;protein SSX3;CT5.3;MGC119054;Cancer/testis antigen 5.3;MGC14495;SSX3_HUMAN;synovial sarcoma, X breakpoint 3, isoform a
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SSX3-2974H | Recombinant Human SSX3, His-tagged | E.coli | Human | His | 1-170aa | |
| SSX3-1447HCL | Recombinant Human SSX3 293 Cell Lysate | HEK293 | Human | Non |
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| SSX3-3705H | Recombinant Human SSX3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
SSX3 involved in several pathways and played different roles in them. We selected most pathways SSX3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SSX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SSX3 has several biochemical functions, for example, nucleic acid binding,protein binding,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SSX3 itself. We selected most functions SSX3 had, and list some proteins which have the same functions with SSX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | BRD7,KCTD1,PROX1,SIRT6,AES,HOMEZA,TGIF1,HSF4,ZMYND11,CTCF |
| nucleic acid binding | MTHFSD,MATR3L,RNASE2,KHDRBS1B,RNASEH1,ZFP503,ZRANB3,ZFP653,RBM14A,BCL11AA |
| protein binding | P2RY1,DGCR8,HMGCR,CCDC112,SENP1,MAP4,CELSR1,PRDM7,C10orf33,CAPN3 |
Interacting Protein
SSX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SSX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SSX3.
RHOJ;MEOX2;AGTRAP;CEP70;MIPOL1;CMTM5;CEP63
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References
- Greve, KBV; Pohl, M; et al. SSX2-4 expression in early-stage non-small cell lung cancer. TISSUE ANTIGENS 83:344-349(2014).
- Gure, AO; Wei, IJ; et al. The SSX gene family: Characterization of 9 complete genes. INTERNATIONAL JOURNAL OF CANCER 101:448-453(2002).
- dos Santos, NR; Torensma, R; et al. Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. CANCER RESEARCH 60:1654-1662(2000).
