SSB
-
Official Full Name
Sjogren syndrome antigen B (autoantigen La) -
Overview
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. -
Synonyms
La;LARP3;La/SSB;La/SSB (Autoimmune RNA Protein);SSB;Sjogren syndrome antigen B (autoantigen La)
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Cynomolgus
- Zebrafish
- Bacillus Anthracis
- Moraxella catarrhalis
- Bacteriophage T7
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- HEK293
- CHO
- Insect Cell
- CHO Cell
- Yeast
- HEK293T
- HEK293 Cells
- Mammalian cells
- GST
- Non
- His
- His&SUMO
- His&Fc&Avi
- His&Myc
- His&Fc
- Myc&DDK
- Flag
Involved Pathway
SSB involved in several pathways and played different roles in them. We selected most pathways SSB participated on our site, such as Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with SSB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Systemic lupus erythematosus | ACTN3,HIST1H2AB,H2AFX,GM14477,HIST1H3G,HIST2H2AA4,Hc,C8G,HIST2H4A,GM14483 |
Protein Function
SSB has several biochemical functions, for example, mRNA binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SSB itself. We selected most functions SSB had, and list some proteins which have the same functions with SSB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | ARF3B,SGK2A,GRK1A,SRSF9,DYRK1AA,HNRNPA1B,UBE2G1B,FUS,SRSF4,ZNF638 |
| protein binding | AKT3,SULT1A2,MEIS1,SIX1,BABAM1,NR2C2AP,CCL18,SRF,RNF126,RABAC1 |
| poly(A) RNA binding | SPATS2,ADAR,HIST1H1E,EIF4H,SRSF12,KHDRBS3,NAP1L4,HARS2,HSP90AA1,TOP3B |
| mRNA binding | RPL35,HNRPLL,RPL13A,QKI,RBFOX1L,RBFOX3,DPPA5A,SLBP,RBM25,MECP2 |
| tRNA binding | EIF2A,EIF2AK4,AARS2,SEPSECS,XPO5,CTU2,XPOT,TRMT1,CTU1,MADD |
Interacting Protein
SSB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SSB here. Most of them are supplied by our site. Hope this information will be useful for your research of SSB.
YBX1;CSNK2A1;positive- sense rna;NR3C1;NME2;RXRB;VHL;Ybx1;YWHAZ;IKBKE;PMVK;Mical3;TNFRSF14;MAP3K14;q99ib8-pro_0000045599;q99ib8-pro_0000045603;Clp1;Nhp2l1
Resources
Related Services
Related Products
References
- Morel, N; Georgin-Lavialle, S; et al. Neonatal lupus syndrome: Literature review. REVUE DE MEDECINE INTERNE 36:159-166(2015).
- Lai, J; Clark, TJ; et al. Ultrasound Findings in Fetal Congenital Heart Block Associated With Maternal Anti-Ro/SSA and Anti-La/SSB Antibodies. ULTRASOUND QUARTERLY 31:34-36(2015).
