SRSF4
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Official Full Name
serine/arginine-rich splicing factor 4 -
Overview
SRp75, also known as Serine/arginine-rich splicing factor 4,Is an essential splicing factor that is a member of the SR family of proteins. This protein is a component of the pre-mRNA splicing complex and is believed to play a role in alternative splice site selection. Consistent with this excess levels of SRp75 have been shown to play a role in alternative splicing of CD45. SRp75 is normally found in the nucleus and is known to be hyperphosphorylated at serine residues in its RS domain. -
Synonyms
SRSF4;serine/arginine-rich splicing factor 4;SFRS4, splicing factor, arginine/serine rich 4;SR splicing factor 4;SRP75;SRP001LB;pre-mRNA-splicing factor SRP75;splicing factor, arginine/serine-rich 4;SFRS4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SRSF4-26856TH | Recombinant Human SRSF4 | Wheat Germ | Human | Non | 77 amino acids |
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| SRSF4-4476R | Recombinant Rhesus monkey SRSF4 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| SRSF4-9977Z | Recombinant Zebrafish SRSF4 | Mammalian Cell | Zebrafish | His |
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| SRSF4-588HCL | Recombinant Human SRSF4 lysate | HEK293 | Human | Non |
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| SRSF4-4292R | Recombinant Rhesus Macaque SRSF4 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SRSF4-4292R-B | Recombinant Rhesus Macaque SRSF4 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
SRSF4 involved in several pathways and played different roles in them. We selected most pathways SRSF4 participated on our site, such as Spliceosome,Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRSF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | SRSF1A,CDC5L,TRA2A,SF3B14,SF3B5,SNRPA,PPIE,TXNL4A,CDC40,SRSF6 |
| Herpes simplex infection | SRSF1A,HCFC2,H2-Q10,EP300,THOC4,TAF4B,HNRPKL,TRAF1,IL6,STAT1A |
Protein Function
SRSF4 has several biochemical functions, for example, nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRSF4 itself. We selected most functions SRSF4 had, and list some proteins which have the same functions with SRSF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | CELF6,CKMB,EK1,ACTA1A,HNRNPABA,STK24A,PRKACAA,CPEB1A,ITPK1A,PTBP2A |
| poly(A) RNA binding | RBM27,PPIB,DDX46,FUS,WIBG,HIST1H4E,DDX49,DIEXF,PCBP2,GDI2 |
Interacting Protein
SRSF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRSF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SRSF4.
RNPS1;YWHAG;SF3A2;SART1;HTATSF1;SRSF10;HAP1;TRA2B;SRSF2;SRSF1;SRSF6;TICAM1;ZDHHC17;PRPF38A;SRRM2;ssrna_ug
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References
- Gencheva, M; Kato, M; et al. Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing. BIOCHEMICAL JOURNAL 429:25-32(2010).
- Espinosa, JM; Portal, D; et al. Trypanosoma cruzi poly-zinc finger protein: a novel DNA/RNA-binding CCHC-zinc finger protein. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 131:35-44(2003).
