SRSF10
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Official Full Name
serine/arginine-rich splicing factor 10 -
Overview
This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. This gene has multiple pseudogenes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist. -
Synonyms
NSSR;TASR;SRp38;TASR1;TASR2;FUSIP1;FUSIP2;SFRS13;SRrp40;SFRS13A;FLJ30749;FLJ43846;DKFZp686H0644;serine/arginine-rich splicing factor 10;OTTHUMP00000015773;OTTHUMP00000015774;OTTHUMP00000015775;OTTHUMP00000015776;OTTHUMP00000015777;OTTHUMP00000015778;SR splicing factor 10;splicing factor SRp38;TLS-associated SR protein;neural-salient SR protein;40 kDa SR-repressor protein;TLS-associated protein TASR;TLS-associated protein with SR repeats;TLS-associated serine-arginine protein 1;TLS-associated serine-arginine protein 2;splicing factor, arginine/serine-rich 13;splicing factor, arginine/serine-rich 13A;serine-arginine repressor protein (40 kDa);TLS-associated protein with Ser-Arg repeats;FUS-interacting serine-arginine-rich protein 1;FUS interacting protein (serine-arginine rich) 1;FUS-interacting protein (serine-arginine rich) 2;serine/arginine-rich splicing factor 10;SRSF10
Recombinant Proteins
- Mouse
- Chicken
- Rhesus macaque
- Human
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- E.coli
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
- His&SUMO
Involved Pathway
SRSF10 involved in several pathways and played different roles in them. We selected most pathways SRSF10 participated on our site, such as Spliceosome,mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRSF10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA processing | PRMT2,HNRNPH2,HNRNPR,WBP4,HNRNPH1,LOC100862398,CELF4,SNRPN,RBM12B1,RBM5 |
| Spliceosome | SNRPA,DDX42,DHX15,NHP2L1,SNW1,SNRPB,TXNL4A,SNRPD2,SRSF6A,NCBP2 |
Protein Function
SRSF10 has several biochemical functions, for example, RNA binding,RS domain binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRSF10 itself. We selected most functions SRSF10 had, and list some proteins which have the same functions with SRSF10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RS domain binding | SRSF5,LUC7L,SRSF12,SRSF1 |
| RNA binding | DDX19B,SRP9,YTHDC1,RBM39A,CPSF3,LRPPRC,SRSF1B,THUMPD2,RAD51AP1,ADARB1A |
| protein binding | FOXK2,NCOA2,HDLBP,GRIN1,FOXP3,EP400,MMP15,TBRG1,PELI3,LHX9 |
| unfolded protein binding | SCG5,HSPA9,HSPE1,LMAN1,CLN3,HSPA1B,HSP90B1,HSPA1A,DNAJB4,CCDC102A |
| nucleotide binding | RDBP,APAF1,NME2B.1,NT5C1AA,ARL15A,SRSF1A,DNM3A,ATP2A2B,CELF3,RBMY1F |
| poly(A) RNA binding | DHX57,DIMT1,SART1,SORBS2,EIF1B,MRPL11,RPL7,APOBEC3B,SNRPD2,ZCCHC9 |
Interacting Protein
SRSF10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRSF10 here. Most of them are supplied by our site. Hope this information will be useful for your research of SRSF10.
YWHAG;SRPK2;SRPK1;YWHAQ;YWHAB;SFN;FUS;TRA2B;SRSF1;SRSF4;GABARAP;EIF4A3;GABARAPL2;MAGOH;GRB2;MZT1;MAP1LC3A;Srek1;SLAIN2
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