SRP54
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Official Full Name
signal recognition particle 54kDa -
Synonyms
SRP54;signal recognition particle 54kDa;signal recognition particle 54 kDa protein;SRP 54;SRP54_HUMAN
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Rat
- Cynomolgus
- Human
- Mammalian Cell
- HEK293
- Baculovirus-Insect cells
- E.coli
- Mammalian cells
- HEK293T
- Insect Cell
- His
- Non
- His&Fc&Avi
- Myc&DDK
- His&B2M
- Flag
Involved Pathway
SRP54 involved in several pathways and played different roles in them. We selected most pathways SRP54 participated on our site, such as Protein export, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRP54 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein export | SRP68,SEC61G,SRP19,SRP14,SEC61A1,SRPRB,SLC38A8,SRP9,SEC11C,secB |
Protein Function
SRP54 has several biochemical functions, for example, 7S RNA binding,GDP binding,GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRP54 itself. We selected most functions SRP54 had, and list some proteins which have the same functions with SRP54. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ribonucleoprotein complex binding | PRMT5,PIGC,CKAP5,PPIH,RNASEL,PRPF31,WDR12,YBX2,SRP54A,SECISBP2 |
| poly(A) RNA binding | ZCCHC3,DHX36,DHX34,PATL1,NCBP1,NUDT16L1,KHDRBS3,PPIE,RPS23,SRFBP1 |
| contributes_to GTPase activity | SRP54A,SRP54B,PIGC |
| endoplasmic reticulum signal peptide binding | PIGC,SRP54A,SRP54B,SRP14,SRP68 |
| 7S RNA binding | EXOSC2,SRP19,PIGC,SRP9,SRP72,SRP14,SRP68,SRP54A |
| GTP binding | GNA11A,EEF2A.1,TUBA1L2,RHOUA,RHOUB,GNAO1B,MTG1,ARL8A,TUBB6,RAB5AB |
| drug binding | PDE2A,HMGCS1,ATP5O,SLC6A4A,P2RX4,P2RX1,MT2A,DRD2,CHRNB4,HTR1B |
| GDP binding | RAB7A,PRPS1,RAB7L1,RAB12,ARL8B,RRAGC,PRPS2,RAB5B,RAN,RAB22A |
Interacting Protein
SRP54 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRP54 here. Most of them are supplied by our site. Hope this information will be useful for your research of SRP54.
hmsS;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;Srp72;STK4;SNW1;Rpl35;CDC5L
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References
- Momomura, M; Miyamae, T; et al. Serum levels of anti-SRP54 antibodies reflect disease activity of necrotizing myopathy in a child treated effectively with combinatorial methylprednisolone pulses and plasma exchanges followed by intravenous cyclophosphamide. MODERN RHEUMATOLOGY 24:529-531(2014).
- Piazzon, N; Schlotter, F; et al. Implication of the SMN complex in the biogenesis and steady state level of the Signal Recognition Particle. NUCLEIC ACIDS RESEARCH 41:1255-1272(2013).
