SRGN

  • Official Full Name

    serglycin

  • Overview

    This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.

  • Synonyms

    SRGN;serglycin;PRG, PRG1, proteoglycan 1, secretory granule;PPG;serglycin proteoglycan;Chondroitin sulfate proteoglycan core protein;Cytolytic granule proteoglycan core protein;FLJ12930;gp600;Hematopoetic proteoglycan core protein;Mastocytoma proteoglycan core protein;MGC9289;OTTHUMP00000019716;P.PG;PG19 core protein;Pgsg;Platelet proteoglycan core protein;platelet proteoglycan protein core;PRG;PRG1;PROTEOGLYCAN 1;proteoglycan 1, secretory granule;Proteoglycan 10K core protein;Proteoglycan peptide core protein;PROTEOGLYCAN PROTEIN CORE FOR MAST CELL SECRETORY GRANULE;secretory granule proteoglycan 1;Secretory granule proteoglycan core protein;Sgc;SRGN_HUMAN;hematopoetic proteoglycan core peptide;secretory granule proteoglycan core peptide;secreto

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Rat
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • Human Cell
  • HEK293
  • Protein Conjugation
  • In Vitro Cell Free System
  • Mammalian cells
  • GST
  • His
  • Non
  • His&GST
  • C-His&Myc
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SRGN-2952H Recombinant Human SRGN, GST-tagged E.coli Human GST 23-158aa
SRGN-15982M Recombinant Mouse SRGN Protein Mammalian Cell Mouse His
SRGN-31396TH Recombinant Human SRGN, His-tagged E.coli Human His 131 amino acids
SRGN-31397TH Recombinant Human SRGN Wheat Germ Human Non 158 amino acids
SRGN-31460TH Recombinant Human SRGN Wheat Germ Human Non 66 amino acids
SRGN-4464R Recombinant Rhesus monkey SRGN Protein, His-tagged Mammalian Cell Rhesus macaque His
SRGN-513H Recombinant Human SRGN, His tagged Human Cell Human His 1-158 a.a.
SRGN-5741R Recombinant Rat SRGN Protein Mammalian Cell Rat His
SRGN-6884H Recombinant Human Serglycin, His-tagged E.coli Human His 28-158aa
SRGN-7672Z Recombinant Zebrafish SRGN Mammalian Cell Zebrafish His
Srgn-8125M Recombinant Mouse Srgn protein, His-tagged E.coli Mouse His Ala28~Ile152
SRGN-1119HCL Recombinant Human SRGN cell lysate Human Cell Human Non
Srgn-2104R Recombinant Rat Srgn Protein, His&GST-tagged E.coli Rat His&GST Arg76-Ile179
SRGN-2369H Recombinant Human SRGN protein(Met1-Leu158), His&Myc-tagged HEK293 Human C-His&Myc Met1-Leu158
SRGN-2624H Recombinant Human SRGN protein(81-150 aa), C-His-tagged E.coli Human His 81-150 aa
SRGN-2734H Recombinant Human SRGN Protein, His-tagged E.coli Human His Tyr28-Leu158
SRGN-2836H Recombinant Human SRGN Protein, His-tagged, OVA Conjugated Protein Conjugation Human His Asp119-Gly148
SRGN-4280R Recombinant Rhesus Macaque SRGN Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
SRGN-4280R-B Recombinant Rhesus Macaque SRGN Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
SRGN-494HF Recombinant Full Length Human SRGN Protein In Vitro Cell Free System Human Full L. 158 amino acids
SRGN-5400R Recombinant Rat SRGN Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
SRGN-5400R-B Recombinant Rat SRGN Protein Pre-coupled Magnetic Beads HEK293 Rat
SRGN-5977H Recombinant Human SRGN Protein (Gly27-Leu158), N-His tagged Mammalian cells Human His Gly27-Leu158
Srgn-6321M Recombinant Mouse Srgn protein, His-tagged E.coli Mouse His 75-152aa
SRGN-8716M Recombinant Mouse SRGN Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
SRGN-8716M-B Recombinant Mouse SRGN Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SRGN involved in several pathways and played different roles in them. We selected most pathways SRGN participated on our site, such as Hemostasis,Platelet activation, signaling and aggregation,Platelet degranulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRGN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Response to elevated platelet cytosolic Ca2+ SCG3,WDR1,IGF2B,SERPINF2B,MMRN1,CD9A,CD9B,F13A1B,STXBP3A,STXBP3
    Hemostasis CD84,KIFC1,KIF9,KIF20A,SLC7A11,MMRN1,TAE1,F3A,PLEK,SIRPA
    Platelet activation, signaling and aggregation IGF2B,CALU,F13A1A.1,SERPINF2B,RHOGA,SPARC,HRG,CD9B,GAS6,BRPF3
    Platelet degranulation F13A1A.1,WDR1,SPARC,MMRN1,AASS,HRG,CD9A,F13A1B,GAS6,BRPF3

    Protein Function

    SRGN has several biochemical functions, for example, collagen binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRGN itself. We selected most functions SRGN had, and list some proteins which have the same functions with SRGN. You can find most of the proteins on our site.

    Function Related Protein
    protein binding CD300A,PSMC1,KIRREL2,DTD2,E2F7,MYEF2,FUS,TUSC2,PRDX3,SRA1
    collagen binding CCBE1,PDGFA,CTSK,ADAM9,GP5,TLL1,SMAD4,SERPINH1,CTSB,GPR56

    Interacting Protein

    SRGN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRGN here. Most of them are supplied by our site. Hope this information will be useful for your research of SRGN.

    SGTA;UBQLN1;UBQLN1;GZMB;VCAN;MMP9;cabc1_provu;PRF1;caf1M;FHL3;q5nem9_fratt

    Resources

    Research Area

    Granzyme

    References

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