SPSB2
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Official Full Name
splA/ryanodine receptor domain and SOCS box containing 2 -
Overview
This gene encodes encodes a suppressor of cytokine signaling (SOCS) family member, and it belongs to the subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal SOCS box. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. -
Synonyms
SPSB2;splA/ryanodine receptor domain and SOCS box containing 2;SPRY domain-containing SOCS box protein 2;GRCC9;SSB 2;gene-rich cluster protein C9;SPRY domain-containing SOCS box protein SSB-2;SSB2;MGC2519;FLJ17395
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- His
- Non
- Myc&DDK
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SPSB2-2942H | Recombinant Human SPSB2, His-tagged | E.coli | Human | His | C-152aa | |
| SPSB2-15951M | Recombinant Mouse SPSB2 Protein | Mammalian Cell | Mouse | His |
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| SPSB2-5726R | Recombinant Rat SPSB2 Protein | Mammalian Cell | Rat | His |
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| SPSB2-7212H | Recombinant Human SplA/ryanodine Receptor Domain And SOCS Box Containing 2, His-tagged | E.coli | Human | His | 1-263aa |
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| SPSB2-1486HCL | Recombinant Human SPSB2 293 Cell Lysate | HEK293 | Human | Non |
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| Spsb2-1060M | Recombinant Mouse Spsb2 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| SPSB2-5319H | Recombinant Human SPSB2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| SPSB2-5385R | Recombinant Rat SPSB2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SPSB2-5385R-B | Recombinant Rat SPSB2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SPSB2-8692M | Recombinant Mouse SPSB2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SPSB2-8692M-B | Recombinant Mouse SPSB2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SPSB2 involved in several pathways and played different roles in them. We selected most pathways SPSB2 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPSB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class I MHC mediated antigen processing & | HUWE1,HECTD3,ATG7,TPP2,ASB11,RNF4,ASB17,TRIM69,UBE2U,RNF6 |
| Proteasome degradation | FBXO3,ASB10,ASB7,ASB14,ASB11,IWS1,RNF25,MKRN1,TRIM39,ASB6 |
| presentation | PJA2,DTX3L,CTSL2,BLMH,HUWE1,LTN1,CYBB,TRIM39,UFL1,ERAP1 |
| Antigen processing: Ubiquitination & | ASB18,RNF41,TRIM63,LRRC41,KLHL20,UBR1,UBE2V2,SPSB1,DTX3L,ASB17 |
| Adaptive Immune System | KIF4A,CD226,HCST,UBE2F,KLRB1B,MKRN1,CTSD,MALT1,DNM2,RASGRP2 |
| Immune System | EVL,ACTR2B,CD300LB,DCTN3,CD200R4,CD200R1,TXN,ASB10,EDAR,CD300LD |
Protein Function
SPSB2 has several biochemical functions, for example, molecular_function,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPSB2 itself. We selected most functions SPSB2 had, and list some proteins which have the same functions with SPSB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | CCDC147,GM15097,ORC3,TNNI2A.3,BEX6,TMEM159,LRRC45,TMEM151B,ADPRM,CEACAM10 |
| protein binding | NAA16,ARNTL1A,SCAMP5,PTTG1,IL10RB,THEM5,MT1A,HGS,GGA2,GTF2E1 |
Interacting Protein
SPSB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPSB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPSB2.
PIK3R3;vas;TCEB1;PRMT1;PAWR;GALNT15;TCEB2;CUL5;RNF7
Resources
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References
- Leung, EWW; Yagi, H; et al. F-19 NMR as a Probe of Ligand Interactions with the iNOS Binding site of SPRY Domain-Containing SOCS Box Protein 2. CHEMICAL BIOLOGY & DRUG DESIGN 84:616-625(2014).
- Yap, BK; Leung, EWW; et al. A Potent Cyclic Peptide Targeting SPSB2 Protein as a Potential Anti-infective Agent. JOURNAL OF MEDICINAL CHEMISTRY 57:7006-7015(2014).
