SPG21
-
Official Full Name
spastic paraplegia 21 (autosomal recessive, Mast syndrome) -
Overview
The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
SPG21;spastic paraplegia 21 (autosomal recessive, Mast syndrome);maspardin;ACP33;BM 019;GL010;MAST;Acid cluster protein 33;BM019;Spastic paraplegia 21 autosomal recessive Mast syndrome protein;OTTHUMP00000164130;spastic paraplegia 21 protein;BM-019
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Rat
- Mouse
- Cynomolgus
- Insect Cells
- Mammalian Cell
- E.coli
- Insect Cell
- HEK293
- HEK293T
- GST
- His
- His&GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SPG21 involved in several pathways and played different roles in them. We selected most pathways SPG21 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPG21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | ERBB3,ADRB3B,VPS24,ARRB2A,DNM1B,FGFR2,MVB12A,SPG20,PIP5K1BB,SH3GLB2A |
Protein Function
SPG21 has several biochemical functions, for example, CD4 receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPG21 itself. We selected most functions SPG21 had, and list some proteins which have the same functions with SPG21. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FBXL5,STYX,PEX11G,SCGB2A2,DHX16,DLG1,RXFP1,PALB2,POU4F1,ARHGEF6 |
| CD4 receptor binding | FYN,LCK,PLSCR1,PLSCR4 |
Interacting Protein
SPG21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPG21 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPG21.
PRPS1;TRAF2;AGTRAP;DTX2;CTPS2
Resources
Related Services
Related Products
References
