SORT1
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Official Full Name
sortilin 1 -
Overview
This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins. [provided by RefSeq, Jul 2008] -
Synonyms
SORT1;sortilin 1;NT3;Gp95;LDLCQ6;sortilin;NTR3;glycoprotein 95;100 kDa NT receptor;neurotensin receptor 3
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian cells
- Wheat Germ
- HEK293
- Mammalian Cell
- Yeast
- GST
- His
- His&SUMO
- His&GST
- His&Avi
- His&Fc&Avi
Involved Pathway
SORT1 involved in several pathways and played different roles in them. We selected most pathways SORT1 participated on our site, such as Lysosome,Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SORT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | SORT1A,SLC11A2,ATP6V0A1B,LAMP2,HGSNAT,DNASE2A,ASAH1A,LAPTM5,AP3B2,CTSSB.2 |
| Neurotrophin signaling pathway | MAPKAPK2,MAPK12,GRB2,NGFR,PIK3R5,ARHGDIB,IRAK4,MAP2K5,NFKBIA,MAP2K2 |
Protein Function
SORT1 has several biochemical functions, for example, enzyme binding,nerve growth factor binding,nerve growth factor receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SORT1 itself. We selected most functions SORT1 had, and list some proteins which have the same functions with SORT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | HYAL2,PTPLAD1,HAND1,ANK1,RPA2,POR,NFKBIA,KALRN,PTPLAD2,ZFP346 |
| nerve growth factor receptor activity | NTRK1 |
| protein binding | C10orf62,SHD,EIF4A2,PMM1,RPH3AL,GGA1,KIFC3,THAP3,PLEKHG6,CEP104 |
| nerve growth factor binding | PCSK6,NGFRB,FURIN,NTRK1,NGFR |
Interacting Protein
SORT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SORT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SORT1.
GGA2;GGA1;LPL;CDK2;NGF
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