SORCS1
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Official Full Name
sortilin-related VPS10 domain containing receptor 1 -
Overview
This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
SORCS1;sortilin-related VPS10 domain containing receptor 1;VPS10 domain-containing receptor SorCS1;VPS10 domain receptor protein SORCS 1;hSorCS;FLJ41758;FLJ43475;FLJ44957
Recombinant Proteins
- Human
- Mouse
- E.coli
- HEK293
- Mammalian cells
- Mammalian Cell
- Human Cell
- Mammalian cell
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SORCS1-2877H | Recombinant Human SORCS1, His-tagged | E.coli | Human | His | 33-156aa | |
| SORCS1-3791H | Recombinant Human SORCS1 protein, His-tagged | HEK293 | Human | His | Ser111-Ser1099 | |
| Sorcs1-737M |
Active Recombinant Mouse Sorcs1 Protein, His-tagged
|
Mammalian cells | Mouse | His | Ser111-Ser1099 |
|
| SORCS1-785H | Recombinant Human SORCS1 | Mammalian Cell | Human | His |
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| SORCS1-1982HCL | Recombinant Human SORCS1 cell lysate | Human Cell | Human | Non |
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| SORCS1-01H | Active Recombinant Human SORCS1 Protein, His tagged | Mammalian cell | Human | His | 111-1099 aa, Ser231Gly |
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| SORCS1-4102H | Recombinant Human SORCS1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| SORCS1-4102H-B | Recombinant Human SORCS1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Sorcs1-8574M | Recombinant Mouse Sorcs1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| Sorcs1-8574M-B | Recombinant Mouse Sorcs1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SORCS1 involved in several pathways and played different roles in them. We selected most pathways SORCS1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SORCS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SORCS1 has several biochemical functions, for example, neuropeptide receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SORCS1 itself. We selected most functions SORCS1 had, and list some proteins which have the same functions with SORCS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NSF,CD81,SP1,TMEM43,MBD4,IFT27,ZNF238,PKP2,DCLRE1C,OSBPL1A |
| neuropeptide receptor activity | SORCS3,KISS1RB,NMUR1,KISS1RA,NPFFR1L1,NPFFR1L3,NPFFR2,PRLHR,NPBWR1,SORCS2 |
Interacting Protein
SORCS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SORCS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SORCS1.
Resources
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References
- Lane, RF; Gatson, JW; et al. Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1. MOLECULAR NEURODEGENERATION 5:-(2010).
- Hermey, G; Keat, SJ; et al. Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells. JOURNAL OF BIOLOGICAL CHEMISTRY 278:7390-7396(2003).
