SORBS3
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Official Full Name
sorbin and SH3 domain containing 3 -
Overview
This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this proteins ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SORBS3;sorbin and SH3 domain containing 3;vinexin;SCAM 1;SH3D4;SCAM1;SH3 containing adapter molecule 1;SH3 domain containing adapter molecule 1;Sorbin and SH3 domain containing protein 3;Vinexin alpha;Vinexin beta (SH3 containing adaptor molecule 1);sorbin and SH3 domain-containing protein 3;vinexin beta (SH3-containing adaptor molecule-1);SCAM-1
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Mammalian Cell
- E.coli
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SORBS3-15758M | Recombinant Mouse SORBS3 Protein | Mammalian Cell | Mouse | His |
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| SORBS3-2227Z | Recombinant Zebrafish SORBS3 | Mammalian Cell | Zebrafish | His |
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| SORBS3-407H | Recombinant Human sorbin and SH3 domain containing 3, His-tagged | E.coli | Human | His | 1-329 a.a. |
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| SORBS3-5008H | Recombinant Human SORBS3, His-tagged | E.coli | Human | His |
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| SORBS3-1669HCL | Recombinant Human SORBS3 cell lysate | Human | Non |
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| SORBS3-8573M | Recombinant Mouse SORBS3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SORBS3-8573M-B | Recombinant Mouse SORBS3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SORBS3 involved in several pathways and played different roles in them. We selected most pathways SORBS3 participated on our site, such as Muscle contraction,Smooth Muscle Contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SORBS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Smooth Muscle Contraction | MYL6B,LMOD1 |
| Muscle contraction | TMOD4,TCAP,CMLC1,SMYHC3,LMOD1,TNNT1,MYBPC2A,TMOD1,TMOD3,TMEM8C |
Protein Function
SORBS3 has several biochemical functions, for example, protein binding,structural constituent of cytoskeleton,transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SORBS3 itself. We selected most functions SORBS3 had, and list some proteins which have the same functions with SORBS3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of cytoskeleton | GFAP,TUBB5,TUBA1C,TUBB,TUBA3E,TUBA3D,CCDC6,TUBA8L3,TUBB6,KRT20 |
| vinculin binding | NRAP,TLN1,PXN,DAG1,SYNM,DMD,ACTN1,CTNNA1,C22orf28 |
| transcription factor binding | GCM1,TWIST1,GTF2A1,E2F2,RBFOX2,HIF1A,KAT2A,MAPK9,NCOA2,H2-AB1 |
| protein binding | PXMP2,TMEM231,EIF2B2,ZNF830,KCNQ1,NUF2,ANKHD1,Siglec1,TYROBP,FZD7 |
Interacting Protein
SORBS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SORBS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SORBS3.
PAK2;KIAA0408;VPS37C;ZBTB7B;TRIM27;TRIM23
Resources
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References
- Sanchez-Mut, JV; Aso, E; et al. DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease. BRAIN 136:3018-3027(2013).
- Pearen, MA; Ryall, JG; et al. Expression profiling of skeletal muscle following acute and chronic beta(2)-adrenergic stimulation: implications for hypertrophy, metabolism and circadian rhythm. BMC GENOMICS 10:-(2009).
