SOCS6
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Official Full Name
suppressor of cytokine signaling 6 -
Overview
The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS1 and SOCS6 interact with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. SOCS1 and SOCS6 inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. These results suggest that SOCS proteins may be inhibitors of IR signalling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes. -
Synonyms
SOCS6;suppressor of cytokine signaling 6;SOCS4, suppressor of cytokine signaling 4;CIS4;Cish4;HSPC060;SSI4;STAI4;STATI4;STAT induced STAT inhibitor-4;cytokine-inducible SH2 protein 4;suppressor of cytokine signaling 4;CIS-4;SOCS4;SOCS-4;SOCS-6
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SOCS6-2873H | Recombinant Human SOCS6, GST-tagged | E.coli | Human | GST | C-term-303aa | |
| SOCS6-2666H | Recombinant Human SOCS6 protein, His-tagged | E.coli | Human | His | 132-385 aa | |
| SOCS6-15747M | Recombinant Mouse SOCS6 Protein | Mammalian Cell | Mouse | His |
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| SOCS6-3839C | Recombinant Chicken SOCS6 | Mammalian Cell | Chicken | His |
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| SOCS6-540H | Recombinant Human SOCS6 Protein, His-tagged | E.coli | Human | His |
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| SOCS6-1577HCL | Recombinant Human SOCS6 293 Cell Lysate | HEK293 | Human | Non |
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| SOCS6-8566M | Recombinant Mouse SOCS6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SOCS6-8566M-B | Recombinant Mouse SOCS6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SOCS6 involved in several pathways and played different roles in them. We selected most pathways SOCS6 participated on our site, such as Jak-STAT signaling pathway,Prolactin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOCS6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Prolactin signaling pathway | SLC2A2,STAT5A,MAPK12,TH,SOCS7,PPIB,SOCS1,GRB2,TNFRSF11A,HRAS |
| Jak-STAT signaling pathway | IFNA10,PIK3CA,IFNA4,TSLP,IL20RA,PRLRA,Il23a; Il12b,IL13RA1,RNF207B,IFNA6 |
Protein Function
SOCS6 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOCS6 itself. We selected most functions SOCS6 had, and list some proteins which have the same functions with SOCS6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TSPAN4,FNIP1,NLRP2,PPIB,H2AFZ,EPS15L1,OCA2,PALB2,HDAC6,RPN1 |
Interacting Protein
SOCS6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOCS6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOCS6.
YAP1;CRK;CLNK;LNX1;APPL1;MET;AR;KIT
SOCS6 Related Signal Pathway
Resources
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References
- Kim, G; Ouzounova, M; et al. SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model. ONCOGENE 34:671-680(2015).
- Cianciulli, A; Dragone, T; et al. IL-10 plays a pivotal role in anti-inflammatory effects of resveratrol in activated microglia cells. INTERNATIONAL IMMUNOPHARMACOLOGY 24:369-376(2015).
