SOCS2
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Official Full Name
suppressor of cytokine signaling 2 -
Overview
Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. -
Synonyms
SOCS2;suppressor of cytokine signaling 2;CIS2;Cish2;SOCS 2;SSI 2;SSI2;STAT induced STAT inhibitor 2;STATI2;CIS-2;STAT induced STAT inhibitor-2;STAT-induced STAT inhibitor 2;STAT-induced STAT inhibitor-2;cytokine-inducible SH2 protein 2;suppressor of cytokine signaling-2;SSI-2;SOCS-2
Recombinant Proteins
- Human
- Rat
- Rhesus macaque
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- His
- Non
- GST
- His&Fc&Avi
Involved Pathway
SOCS2 involved in several pathways and played different roles in them. We selected most pathways SOCS2 participated on our site, such as Jak-STAT signaling pathway,Insulin signaling pathway,Prolactin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOCS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin signaling pathway | RAPGEF1B,TSC1B,SOCS1A,SOCS9,PPP1R3DA,HK3,PPP1R3A,TRIP10,PPP1R3C,SOCS3 |
| Prolactin signaling pathway | NEK3,MAPK9,GALT,PIK3R5,TH,SOCS5,PIK3CB,STAT3,SRC,RELA |
| Jak-STAT signaling pathway | STAT5B,STAM,IL2RGA,STAT6,PIK3R3B,AOX4,CCND1,IL2RG,AKT2,CSH2 |
| Type II diabetes mellitus | MAPK10,MAPK8,PRKCZ,PIK3CB,PIK3R5,PRKCE,IKBKB,HK2,PIK3CA,IRS2 |
Protein Function
SOCS2 has several biochemical functions, for example, JAK pathway signal transduction adaptor activity,SH3/SH2 adaptor activity,growth hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOCS2 itself. We selected most functions SOCS2 had, and list some proteins which have the same functions with SOCS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| JAK pathway signal transduction adaptor activity | SH2B2 |
| SH3/SH2 adaptor activity | SH3BGR,ARHGAP4,RUSC1,CNTNAP1,CHN1,FCRL2,SLA2,BLNK,SH2D3C,CRKL |
| growth hormone receptor binding | Gh,JAK1,GH1,TYK2,JAK2 |
| insulin-like growth factor receptor binding | INS2,YWHAG,IGF2A,IGF2,SHC1,Ren1,ARRB1,YWHAH,INS,SOCS1 |
| protein binding | DTX3,ZMYM2,ROCK2A,VDAC1,ABHD14B,EFCAB12,MSMB,RBMX,HPGDS,GPSM2 |
Interacting Protein
SOCS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOCS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOCS2.
TCEB1;MET;KIT;PLA2G1B;EPOR;BMI1;ARFIP2;TPD52;Tceb1;GHR
SOCS2 Related Signal Pathway
Resources
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References
- Hu, J; Lou, DH; et al. LPS Regulates SOCS2 Transcription in a Type I Interferon Dependent Autocrine-Paracrine Loop. PLOS ONE 7:-(2012).
- Gilli, F; Navone, ND; et al. Loss of Braking Signals During Inflammation A Factor Affecting the Development and Disease Course of Multiple Sclerosis. ARCHIVES OF NEUROLOGY 68:879-888(2011).
