SNX9
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Official Full Name
sorting nexin 9 -
Overview
This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013] -
Synonyms
SNX9;sorting nexin 9;SDP1;WISP;SH3PX1;SH3PXD3A;sorting nexin-9;SH3 and PX domain-containing protein 1;SH3 and PX domain-containing protein 3A;Wiskott-Aldrich syndrome protein (WASP) interactor protein
Recombinant Proteins
- Human
- Mouse
- E.coli
- HEK293
- Mammalian cells
- HEK293T
- His
- His&T7
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SNX9-3536H | Recombinant Human SNX9 protein, His-tagged | E.coli | Human | His | 1-362 aa | |
| SNX9-1367H | Recombinant Human SNX9 protein, His & T7-tagged | E.coli | Human | His&T7 | Phe250~Met595 |
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| SNX9-1584HCL | Recombinant Human SNX9 293 Cell Lysate | HEK293 | Human | Non |
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| SNX9-2066H | Recombinant Human SNX9 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| SNX9-2066H-B | Recombinant Human SNX9 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| SNX9-536HFL | Recombinant Full Length Human SNX9 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| SNX9-5901H | Recombinant Human SNX9 Protein (Phe250-Met595), N-His tagged | E.coli | Human | His | Phe250-Met595 |
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| Snx9-6039M | Recombinant Mouse Snx9 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
SNX9 involved in several pathways and played different roles in them. We selected most pathways SNX9 participated on our site, such as Clathrin derived vesicle budding,Golgi Associated Vesicle Biogenesis,Membrane Trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Membrane Trafficking | COPB2,TRAPPC1,CNIH,TRAPPC2,MCFD2,GJB3,EXOC8,CNO,LMAN2L,EXOC3 |
| trans-Golgi Network Vesicle Budding | PICALMA,CNO,TPD52L1,TGOLN2,PICALMB,PLDN,CLVS1,FTH1B,PICALM,TFR1B |
| Clathrin derived vesicle budding | AP1M2,CTSZ,FTH1A,DTNBP1,ARF1,AP1S3A,AP3S1,AP1B1,TPD52,YIPF6 |
| Vesicle-mediated transport | AMBP,SCFD1,GJB7,TGOLN2,GJA5,RALAA,GJA4,ANKRD28,SNF8,TRAPPC5 |
| Golgi Associated Vesicle Biogenesis | CLINT1,HIP1R,NECAP1,AP1S3A,AP1S1,AP3S1,TPD52,CPD,BLOC1S4,TBC1D8B |
Protein Function
SNX9 has several biochemical functions, for example, 1-phosphatidylinositol binding,Arp2/3 complex binding,phosphatidylinositol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX9 itself. We selected most functions SNX9 had, and list some proteins which have the same functions with SNX9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | UGT1A6B,PDGFB,LMLN,HPGDS,RPL7,SNX2,CADM1,AOC3,PVRL4,IZUMO1 |
| ubiquitin protein ligase binding | CASP10,PIAS1,WFS1,HSPA1A,TPI1,NDUFS2,CALR,TRIB2,PRKAR1A,LTBR |
| 1-phosphatidylinositol binding | SCIN,PICALM,ZFYVE9,SCARB1,MCF2L,ZFYVE16,PICALMA,SNAP91,EEA1,FRMPD2 |
| Arp2/3 complex binding | PICK1,GMFB,HAND2,GMFG,WHAMM,CORO1B,ARPC2 |
| protein binding | GNA14,MYBL2,ARMC9,LRP2,PELI2,SENP3,ALDOB,MAGEA4,FOXP1,CSNK2A2 |
| phosphatidylinositol binding | SNX1A,RPS6KC1,SNX15,SNX13,SNX19A,SNX1,HIP1,WDR35,SNX6,TNFAIP8L3 |
Interacting Protein
SNX9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX9 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX9.
DNM1;DNM2;ITCH;espF
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References
- Tahoun, A; Siszler, G; et al. Comparative Analysis of EspF Variants in Inhibition of Escherichia coli Phagocytosis by Macrophages and Inhibition of E. coli Translocation through Human- and Bovine-Derived M Cells. INFECTION AND IMMUNITY 79:4716-4729(2011).
- Macaulay, SL; Stoichevska, V; et al. Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. BIOCHEMICAL JOURNAL 376:123-134(2003).
