SNUPN
-
Official Full Name
snurportin 1 -
Overview
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. -
Synonyms
SNUPN;snurportin 1;RNA, U transporter 1 , RNUT1;snurportin-1;Snurportin1;0610031A09Rik;KPNBL;MGC134006;MGC95000;RNA U transporter 1;RNA, U transporter 1;RNUT 1;RNUT1;Snupn1;SPN1;SPN1_HUMAN;wu:fc41a03;zgc:77819;OTTHUMP00000183516
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SNUPN involved in several pathways and played different roles in them. We selected most pathways SNUPN participated on our site, such as Gene Expression,Metabolism of non-coding RNA,RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNUPN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| snRNP Assembly | DDX20,WDR77,PEAK1,CLNS1A |
| Metabolism of non-coding RNA | PEAK1,WDR77,DDX20,CLNS1A,PRMT5 |
| Gene Expression | ZNF12,ZNF498,ZNF10,ZFP90,TRMT112,CTGF,ZNF468,ZNF556,ZNF615,PUS1 |
| RNA transport | TACC3,PABPC5,EIF4A1A,TPR,GEMIN8,SUMO2,POP4,EIF3HA,EIF4A1B,FMR1 |
Protein Function
SNUPN has several biochemical functions, for example, RNA cap binding,protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SNUPN itself. We selected most functions SNUPN had, and list some proteins which have the same functions with SNUPN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA cap binding | EIF4E,EIF4G3,EIF4A1,NCBP1,LARP1,EIF4E2,NCBP2 |
| protein transporter activity | KPNA2,COG3,RAB4A,CALCR,AP2S1,DPY19L2,AP1G2,PPIAL4A,RAP1A,IPO13 |
Interacting Protein
SNUPN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNUPN here. Most of them are supplied by our site. Hope this information will be useful for your research of SNUPN.
GCNT3;ENO2;RPL17;TNNT3;PEX5;PAFAH1B2;DBN1;MEX3B;RNF126;KIAA1107;SLC33A1;YEATS4;XRCC5;SNW1;Dync1li1;Tor1aip1
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References
- Yoon, JH; Abdelmohsen, K; et al. Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. NATURE COMMUNICATIONS 4:-(2013).
- Ohkubo, A; Kondo, Y; et al. Chemical Synthesis of U1 snRNA Derivatives. ORGANIC LETTERS 15:4386-4389(2013).
