SNCB
-
Official Full Name
synuclein, beta -
Overview
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
SNCB;synuclein, beta;beta-synuclein
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- N-His&C-Myc
Involved Pathway
SNCB involved in several pathways and played different roles in them. We selected most pathways SNCB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SNCB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SNCB has several biochemical functions, for example, calcium ion binding,phospholipase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SNCB itself. We selected most functions SNCB had, and list some proteins which have the same functions with SNCB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CCDC48,SLIT3,DNER,CHP1,EHD1,NCS1,NELL2A,PKD2,DNASE1L3,PROZ |
| phospholipase inhibitor activity | ANXA5,ANXA3B,ANXA3A,ANXA1A,APOC1,ANXA2A,ANXA4,ANXA1C,ANGPTL3,ANXA2B |
Interacting Protein
SNCB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNCB here. Most of them are supplied by our site. Hope this information will be useful for your research of SNCB.
SNCAIP;AKT1;CENPT
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References
- Viola, KL; Klein, WL; et al. Amyloid beta oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis. ACTA NEUROPATHOLOGICA 129:183-206(2015).
- Mukaetova-Ladinska, EB; Abdel-All, Z; et al. Tau Proteins in the Temporal and Frontal Cortices in Patients With Vascular Dementia. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 74:148-157(2015).
