SMPD2
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Official Full Name
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) -
Overview
Sphingomyelinases (SMases) catalyze the hydrolysis of sphingomyelin to produce ceramide and phosphocholine. Ceramide is an important bioactive lipid triggering signal transduction involved in cell proliferation, apoptosis and differentiation. A number of -
Synonyms
SMPD2;sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase);sphingomyelin phosphodiesterase 2;ISC1;nSMase;N-SMase;lyso-PAF-PLC;neutral sphingomyelinase;lyso-platelet-activating factor-phospholipase C;NSMASE1
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Rat
- Mus musculus
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- E.coli expression system
- In vitro E. coli expression system
- In Vitro Cell Free System
- His
- GST
- His&GST
- Non
- His&Fc&Avi
Involved Pathway
SMPD2 involved in several pathways and played different roles in them. We selected most pathways SMPD2 participated on our site, such as Sphingolipid metabolism,Metabolic pathways,Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMPD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid metabolism | ACER3,CERS4A,ACER1,SPTLC2B,DEGS2,NEU3.4,PPAP2D,NEU3.5,ASAH1B,SMPD1 |
| Metabolic pathways | GLCE,EBP,PDXKA,LPIN3,UROC1,AMY2A5,FBP1,DGKE,SYNJ1,BDH1 |
| Sphingolipid signaling pathway | RAC1,ASAH2,SMPD1,MAP2K2,MAPK10,ACER1,PLCB2,PPP2R2C,PPP2R5D,PPP2CA |
Protein Function
SMPD2 has several biochemical functions, for example, metal ion binding,sphingomyelin phosphodiesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMPD2 itself. We selected most functions SMPD2 had, and list some proteins which have the same functions with SMPD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | SDHDB,FURIN,BAK1,HPDB,ME2,PITPNM1,ELAC1,YME1L1,SCRT1,ANKMY1 |
| sphingomyelin phosphodiesterase activity | ENPP7,SMPD3,SMPDL3A,SMPD4,SMPD5,SMPD2A,SMPDL3B,SMPD1 |
Interacting Protein
SMPD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMPD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMPD2.
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