SLC6A5
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Official Full Name
solute carrier family 6 (neurotransmitter transporter, glycine), member 5 -
Overview
This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane;glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This;protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic;synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by;exaggerated startle responses and neonatal apnea. -
Synonyms
SLC6A5;solute carrier family 6 (neurotransmitter transporter, glycine), member 5;NET1;sodium- and chloride-dependent glycine transporter 2;GLYT2;Glycine transporter;Glycine transporter type 2;SC6AC5;SLC6A5 solute carrier family 6 neurotransmitter transporter, glycine member 5;Slc6a9;Sodium and chloride dependent glycine transporter 2;Solute carrier family 6 member 5;Solute carrier family 6 neurotransmitter transporter glycine member 5;OTTHUMP00000231736;GLYT-2
Recombinant Proteins
- Human
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Insect Cell
- His
- GST
- Non
- His&Flag&Strep
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC6A5-2951H | Recombinant Human SLC6A5 protein, His-tagged | E.coli | Human | His | 1-200 aa |
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| SLC6A5-118H | Recombinant Human SLC6A5 protein, GST-tagged | Wheat Germ | Human | GST | 294-393 a.a. |
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| SLC6A5-1947Z | Recombinant Zebrafish SLC6A5 | Mammalian Cell | Zebrafish | His |
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| SLC6A5-683H | Recombinant Human SLC6A5 | Mammalian Cell | Human | His |
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| SLC6A5-1704HCL | Recombinant Human SLC6A5 293 Cell Lysate | HEK293 | Human | Non |
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| SLC6A5-1207H | Recombinant Human SLC6A5 Protein (D2-C797), 8×His-Strep, Flag tagged | Insect Cell | Human | His&Flag&Strep | D2-C797 |
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| SLC6A5-4083H | Recombinant Human SLC6A5 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| SLC6A5-4083H-B | Recombinant Human SLC6A5 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
SLC6A5 involved in several pathways and played different roles in them. We selected most pathways SLC6A5 participated on our site, such as Na+/Cl- dependent neurotransmitter transporters,SLC-mediated transmembrane transport,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC6A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transmembrane transport of small molecules | TRPA1B,AQP10,SLC20A2,RHAG,WNK2,SLC39A2,SLC43A1A,SLC1A2A,ABCD3B,SLC1A7A |
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | SLC30A6,SLC39A10,SLC6A6A,CP,SLC6A9,SLC22A7,SLC16A7,SLC22A16,RHAG,SLC30A8 |
| SLC-mediated transmembrane transport | SLC22A16,SLC13A3,RHCGL1,SLC39A14,SLC26A7,SLC22A6,SLC12A5B,SLC9A8,SLC6A1A,SLC35A3 |
| Na+/Cl- dependent neurotransmitter transporters | SLC6A6A,SLC6A6,SLC6A15,SLC6A1B,SLC6A7,SLC6A1A,SLC6A11,SLC6A18,SLC6A19A,SLC6A12 |
Protein Function
SLC6A5 has several biochemical functions, for example, glycine:sodium symporter activity,neurotransmitter:sodium symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC6A5 itself. We selected most functions SLC6A5 had, and list some proteins which have the same functions with SLC6A5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| neurotransmitter:sodium symporter activity | SLC6A19B,SLC6A9,SLC6A4B,SLC6A6A,SLC6A13L,SLC6A8,SLC6A15,SLC6A18,SLC6A1B,SLC6A6 |
| glycine:sodium symporter activity | SLC6A9 |
Interacting Protein
SLC6A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC6A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC6A5.
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References
- Sherman, D; Worrell, JW; et al. Optogenetic perturbation of preBotzinger complex inhibitory neurons modulates respiratory pattern. NATURE NEUROSCIENCE 18:408-414(2015).
- Arribas-Gonzalez, E; de Juan-Sanz, J; et al. Molecular Basis of the Dominant Negative Effect of a Glycine Transporter 2 Mutation Associated with Hyperekplexia. JOURNAL OF BIOLOGICAL CHEMISTRY 290:2150-2165(2015).
