SLC6A3
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Official Full Name
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 -
Synonyms
SLC6A3;solute carrier family 6 (neurotransmitter transporter, dopamine), member 3;sodium-dependent dopamine transporter;DA transporter;dopamine transporter 1;solute carrier family 6 member 3;DAT;Dat1
Recombinant Proteins
- Human
- Mouse
- Rat
- Rhesus macaque
- Zebrafish
- Cynomolgus
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&GST
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
SLC6A3 involved in several pathways and played different roles in them. We selected most pathways SLC6A3 participated on our site, such as Dopaminergic synapse,Parkinsons disease,Cocaine addiction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC6A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cocaine addiction | CREB3L2,DDC,GRIN2D,SLC18A1,TH,GRM2,GNAI3,FOSB,PRKACG,GRIN2B |
| Dopaminergic synapse | MAPK10,GNB3,MAOB,PRKCA,ARRB2,PPP1CC,CALY,CALM4,ARNTL,CREB5 |
| Parkinsons disease | UCHL1,Casp3,NDUFA5,GPR37,CYCS,NDUFAB1,Atp5g2,NDUFS8,UBE2J2,NDUFV3 |
| Alcoholism | H3F3B,HIST1H2AL,HIST1H2BB,H2AFY2,HDAC2,HDAC7,HIST1H2AF,PKIA,HIST1H2AK,GNAI3 |
Protein Function
SLC6A3 has several biochemical functions, for example, dopamine binding,dopamine transmembrane transporter activity,dopamine:sodium symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC6A3 itself. We selected most functions SLC6A3 had, and list some proteins which have the same functions with SLC6A3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SYCE3,SND1,PLN,LTBP1,DNMT3B,CEP44,ITGA1,MLLT3,ELMO3,Pilrb1 |
| monoamine transmembrane transporter activity | SLC18A1,SLC6A2,SLC22A1,SLC6A4,SLC18A2,SLC29A4 |
| protein N-terminus binding | STX5A,FEZ1,PEX14,PDCD10,SMARCC1,ERCC2,PEX5,SDCBP,PIAS3,STX1A |
| dopamine transmembrane transporter activity | SLC22A2,SLC22A1,SLC22A3 |
| dopamine binding | DRD3,DRD2A,DRD1A,ADRB2,DRD2B,DRD1B,DRD2L,TH,DRD1,DRD4 |
Interacting Protein
SLC6A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC6A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC6A3.
SNCA;PICK1;DRD2;gbr12909-vanoxerine;gbr12935;TPPP;Pick1
Resources
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References
- Fabbri, C; Porcelli, S; et al. From Pharmacogenetics to Pharmacogenomics: The Way Toward the Personalization of Antidepressant Treatment. CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE 59:62-75(2014).
- Higuchi, M; Miura, C; et al. Trypsin Regulates Meiotic Initiation in the Japanese Eel (Anguilla japonica) by Promoting the Uptake of Taurine into Germ Cells During Spermatogenesis. BIOLOGY OF REPRODUCTION 89:-(2013).
