SLC4A4
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Official Full Name
solute carrier family 4, sodium bicarbonate cotransporter, member 4 -
Overview
This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SLC4A4;solute carrier family 4, sodium bicarbonate cotransporter, member 4;electrogenic sodium bicarbonate cotransporter 1;NBC-like protein;Na+HCO3- cotransporter 4;Na(+)/HCO3(-) cotransporter;sodium bicarbonate cotransporter;solute carrier family
Recombinant Proteins
- Human
- Rat
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC4A4-2775H | Recombinant Human SLC4A4, GST-tagged | E.coli | Human | GST | 25-354aa | |
| SLC4A4-31418TH | Recombinant Human SLC4A4, His-tagged | E.coli | Human | His | 424 amino acids |
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| SLC4A4-31419TH | Recombinant Human SLC4A4, His-tagged | E.coli | Human | His | 1-424 a.a. |
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| SLC4A4-505H | Recombinant Human SLC4A4 , His-tagged | E.coli | Human | His |
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| SLC4A4-5551R | Recombinant Rat SLC4A4 Protein | Mammalian Cell | Rat | His |
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| SLC4A4-5210R | Recombinant Rat SLC4A4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SLC4A4-5210R-B | Recombinant Rat SLC4A4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
SLC4A4 involved in several pathways and played different roles in them. We selected most pathways SLC4A4 participated on our site, such as Proximal tubule bicarbonate reclamation,Pancreatic secretion,Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC4A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pancreatic secretion | PLCB4,TPCN2,ITPR1,ITPR3,PLA2G2F,ATP1A1,CTRB1,RAB3D,BST1,Car2 |
| Proximal tubule bicarbonate reclamation | GLS2,ATP1B4,ATP1B3,GLS,CA4,ATP1A2,GLUD1,Car4,MDH1,PCK1 |
| Bile secretion | SCARB1,SLC10A1,SLC10A2,PRKACB,NR0B2,PRKACA,EPHX1,ADCY3,ABCB1,ATP1B2 |
Protein Function
SLC4A4 has several biochemical functions, for example, inorganic anion exchanger activity,protein binding,sodium:bicarbonate symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC4A4 itself. We selected most functions SLC4A4 had, and list some proteins which have the same functions with SLC4A4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sodium:bicarbonate symporter activity | SLC26A6L,SLC4A8,SLC4A4A,SLC26A3.1 |
| inorganic anion exchanger activity | SLC4A1A,SLC22A20,SLC22A6,SLC4A3,SLC22A24,SLC4A1B,SLC4A1,SLC22A8,SLC4A11,SLC4A2B |
| protein binding | DNAJC27,TXNRD3,LILRB2,SCIMP,ZHX1,UCN,H2-AB1,ZBTB26,STMN1,KCNG3 |
Interacting Protein
SLC4A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC4A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC4A4.
CA4;SREBF2;glpF
Resources
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References
- Jalali, R; Guo, J; et al. NBCe1 (SLC4A4) a potential pH regulator in enamel organ cells during enamel development in the mouse. CELL AND TISSUE RESEARCH 358:433-442(2014).
- Gregorio, SF; Carvalho, ESM; et al. Endocrine regulation of carbonate precipitate formation in marine fish intestine by stanniocalcin and PTHrP. JOURNAL OF EXPERIMENTAL BIOLOGY 217:1555-1562(2014).
