SLC39A8
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Official Full Name
solute carrier family 39 (zinc transporter), member 8 -
Overview
This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. -
Synonyms
SLC39A8;solute carrier family 39 (zinc transporter), member 8;solute carrier family 39 (metal ion transporter), member 8;zinc transporter ZIP8;BIGM103;ZIP-8;Zrt- and Irt-like protein 8;solute carrier family 39 member 8;LIV-1 subfamily of ZIP zinc
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC39A8-1878H | Recombinant Human SLC39A8 protein, GST-tagged | E.coli | Human | GST | 18-143 aa | |
| SLC39A8-15441M | Recombinant Mouse SLC39A8 Protein | Mammalian Cell | Mouse | His |
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| SLC39A8-5535R | Recombinant Rat SLC39A8 Protein | Mammalian Cell | Rat | His |
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| SLC39A8-5194R | Recombinant Rat SLC39A8 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SLC39A8-5194R-B | Recombinant Rat SLC39A8 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SLC39A8-671H | Recombinant Human SLC39A8 Protein, GST-tagged | Wheat Germ | Human | GST | 1-460 aa |
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| SLC39A8-6817HF | Recombinant Full Length Human SLC39A8 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 460 amino acids |
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| SLC39A8-8370M | Recombinant Mouse SLC39A8 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SLC39A8-8370M-B | Recombinant Mouse SLC39A8 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SLC39A8 involved in several pathways and played different roles in them. We selected most pathways SLC39A8 participated on our site, such as Metal ion SLC transporters,SLC-mediated transmembrane transport,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC39A8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | SLC30A1A,SLC22A18,SLC13A1,SLC39A3,RHCG,MATE4,SLC2A6,SLC39A14,SLC6A20A,SLC13A5A |
| Transmembrane transport of small molecules | FKBP1B,SLCO4C1,SLC41A1,ANKHA,SLC17A7A,TRPM1B,SLC14A1,ADD2,SLC22A7B.1,SLC30A5 |
| Zinc influx into cells by the SLC39 gene family | SLC39A2,SLC39A7,SLC39A10,SLC39A3,SLC39A6,SLC39A5,SLC39A1,SLC39A14 |
| Metal ion SLC transporters | SLC39A3,SLC39A10,SLC30A3,SLC39A1,SLC30A6,SLC30A2,SLC31A1,SLC30A1A,SLC39A5,SLC30A1B |
| Zinc transporters | SLC39A10,SLC30A1B,SLC39A14,SLC39A1,SLC39A2,SLC39A5,SLC39A3,SLC30A3,SLC30A2,SLC39A6 |
| SLC-mediated transmembrane transport | SLC1A3A,SLC26A3.1,SLC39A7,SLC1A4,SLC2A12,SLC28A1,SLC6A6,SLC43A2B,SLC4A3,PDZD11 |
Protein Function
SLC39A8 has several biochemical functions, for example, metal ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC39A8 itself. We selected most functions SLC39A8 had, and list some proteins which have the same functions with SLC39A8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion transmembrane transporter activity | SLC39A9,SLC39A14,SLC39A5,SLC39A6 |
Interacting Protein
SLC39A8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC39A8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC39A8.
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