SLC26A4
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Official Full Name
solute carrier family 26, member 4 -
Overview
Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3 of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. -
Synonyms
SLC26A4;solute carrier family 26, member 4;DFNB4;pendrin;PDS;deafness, autosomal recessive 4;EVA;NSRD4;Pendred syndrome;Pendred syndrome homolog;S26A4_HUMAN;Sodium independent chloride/iodide transporter;Sodium-independent chloride/iodide transporter;Solute carrier family 26 member 4;OTTHUMP00000206717;TDH2B
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In vitro E. coli expression system
- Mamanlian cells
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
SLC26A4 involved in several pathways and played different roles in them. We selected most pathways SLC26A4 participated on our site, such as Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC26A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone synthesis | ATP1B3,GPX5,GPX2,PRKACA,CREB3L2,GPX1,ITPR1,CANX,ATF4,HSPA5 |
Protein Function
SLC26A4 has several biochemical functions, for example, anion:anion antiporter activity,bicarbonate transmembrane transporter activity,chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC26A4 itself. We selected most functions SLC26A4 had, and list some proteins which have the same functions with SLC26A4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chloride transmembrane transporter activity | SLC4A1,SLC26A1,SLC26A6,SLC26A3,CFTR,Slc4a2 |
| chloride channel activity | CLIC3,GABRA5,SLC26A3.2,ANO2,GABRB2,CLCN7,GABRA6,BEST1,CLCA5,CLCA2 |
| secondary active sulfate transmembrane transporter activity | SLC26A11,SLC26A2,SLC13A1,SLC26A7,SLC26A3,SLC26A3.2,SLC26A5,SLC26A1,SLC26A9,SLC26A3.1 |
| oxalate transmembrane transporter activity | SLC26A7,SLC26A6,SLC26A2,SLC26A5,SLC26A9,SLC26A3.2,SLC26A1,SLC26A3.1,SLC26A11,SLC26A3 |
| anion:anion antiporter activity | SLC4A2B,SLC26A2,SLC4A8,SLC4A2A,SLC26A3.2,SLC26A1,SLC26A6L,SLC26A11,SLC26A3.1,SLC4A1 |
| iodide transmembrane transporter activity | SLC5A5 |
| bicarbonate transmembrane transporter activity | SLC26A3.2,SLC4A1,SLC4A1B,SLC26A7,SLC26A6,SLC26A1,SLC26A11,SLC26A9,SLC4A11,SLC26A5 |
| sulfate transmembrane transporter activity | SLC26A2,SLC26A3.1,SLC26A6,SLC26A7,SLC26A1,SLC26A5,SLC26A11,SLC26A9,SLC26A3,SLC26A3.2 |
Interacting Protein
SLC26A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC26A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC26A4.
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