SLC25A5
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Official Full Name
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -
Overview
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene. -
Synonyms
SLC25A5;solute carrier family 25 (mitochondrial carrier;adenine nucleotide translocator), member 5;ANT2;ADP/ATP translocase 2;2F1;T2;T3;ANT 2;ADP/ATP carrier protein;ADP,ATP carrier protein 2;solute carrier family 25 member 5;ADP,ATP carrier p
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- Bovine
- Tachyglossus aculeatus aculeatus (Southeast Australian short-beaked echidna)
- Mus musculus
- Pongo Abelii
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- HEK293
- E.coli expression system
- Insect Cell
- HEK293T
- Mammalian cells
- His
- Non
- His&Flag&MBP
- His&Flag&Strep
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
SLC25A5 involved in several pathways and played different roles in them. We selected most pathways SLC25A5 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC25A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Parkinsons disease | UBB,COX7A2L,TH,SLC25A4,NDUFS8,UBE2J1,CYCS,NDUFB3,PPIF,UBE2J2 |
| Calcium signaling pathway | PTGER1B,CACNA1H,PHKG2,HTR4,PTGER1C,AGTR1B,P2RX3A,SLC8A1B,PLCD1B,PPP3CA |
| HTLV-I infection | APC2,ANAPC4,NFKB2,WNT3A,CDC20,CRTC1,ANAPC1,TBP,WNT1,PCNA |
| cGMP-PKG signaling pathway | ITPR1,ITPR3,IRS4,ATP1B4,MYLK,AGTR1B,NFATC1,PIK3R1,PIK3CA,GNAI1 |
| Huntingtons disease | PLCB4,DNALC4,GRIN1,HDAC1,NDUFB3,NDUFA10,NDUFA4L2,NDUFA1,NDUFC2,NDUFS7 |
Protein Function
SLC25A5 has several biochemical functions, for example, adenine transmembrane transporter activity,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC25A5 itself. We selected most functions SLC25A5 had, and list some proteins which have the same functions with SLC25A5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | AKAP8L,LSM3,PTCD3,CNOT1,TPT1,PCBP2,OASL,RBPMS,PPIA,SNRNP200 |
| adenine transmembrane transporter activity | SLC25A4 |
| ubiquitin protein ligase binding | RELA,RNF40,UBE2G1B,UBE2V1,KCNH2,DNAJA1,TSG101,RIPK1,SCAMP3,PINK1 |
| protein binding | ADARB1,CSPP1,MAP4K3,FAM50B,EHMT2,DDOST,MRM1,SRGAP2,TIMELESS,MAP1B |
Interacting Protein
SLC25A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC25A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC25A5.
LRRK2;P;ESR1;NCK2;TNFRSF1A;TNFRSF1B;NFKBIA;RELA;TRAF2;TRAF1;MAP3K1;RIPK1;TRADD;SMAD2;SLC35F6;MAP3K3
Resources
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References
- Di Noia, MA; Todisco, S; et al. The Human SLC25A33 and SLC25A36 Genes of Solute Carrier Family 25 Encode Two Mitochondrial Pyrimidine Nucleotide Transporters. JOURNAL OF BIOLOGICAL CHEMISTRY 289:33137-33148(2014).
- Porcelli, V; Fiermonte, G; et al. The Human Gene SLC25A29, of Solute Carrier Family 25, Encodes a Mitochondrial Transporter of Basic Amino Acids. JOURNAL OF BIOLOGICAL CHEMISTRY 289:13374-13384(2014).
