SLC25A27
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Official Full Name
solute carrier family 25, member 27 -
Overview
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants. -
Synonyms
SLC25A27;solute carrier family 25, member 27;mitochondrial uncoupling protein 4;FLJ33552;UCP4;UCP 4;uncoupling protein 4;RP11-446F17.2
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Human
- Mammalian Cell
- E.coli
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC25A27-10665Z | Recombinant Zebrafish SLC25A27 | Mammalian Cell | Zebrafish | His |
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| SLC25A27-4250R | Recombinant Rhesus monkey SLC25A27 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| SLC25A27-544H | Recombinant Human SLC25A27 Protein, His-tagged | E.coli | Human | His |
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| SLC25A27-1773HCL | Recombinant Human SLC25A27 293 Cell Lysate | HEK293 | Human | Non |
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| RFL34378HF | Recombinant Full Length Human Mitochondrial Uncoupling Protein 4(Slc25A27) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-323) |
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| SLC25A27-402H | Recombinant Human SLC25A27 Protein, His-tagged | E.coli | Human | His | Ser21-Met317 |
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| SLC25A27-4066R | Recombinant Rhesus Macaque SLC25A27 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SLC25A27-4066R-B | Recombinant Rhesus Macaque SLC25A27 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
SLC25A27 involved in several pathways and played different roles in them. We selected most pathways SLC25A27 participated on our site, such as Electron Transport Chain,Metabolism,Mitochondrial Uncoupling Proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC25A27 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| The fatty acid cycling model | UCP2,UCP3,SLC25A14 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | NDUFAF3,COX11,ATP5L,NDUFAF4,ETFA,TIMMDC1,COX16,SLC25A14,SURF1,C2orf56 |
| Metabolism | ECI1,RHAG,CYP4T8,ESRRA,MARCKSB,UGT1B3,NUDT16,SLC25A13,DDAH1,HSD17B11 |
| The citric acid (TCA) cycle and respiratory electron transport | D2HGDH,PDPR,LRPPRC,ETFB,ADHFE1,ATP5S,BRP44,ETFA,SURF1,MPC1 |
| Electron Transport Chain | COX5B,ATP5H,COX4I1,COX6C,COX6A1,ATP5S,UCP2,COX11,NDUFC2-KCTD14,COX7A2 |
| The proton buffering model | SLC25A14 |
| Mitochondrial Uncoupling Proteins | UCP3,SLC25A14,UCP2 |
Protein Function
SLC25A27 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by SLC25A27 itself. We selected most functions SLC25A27 had, and list some proteins which have the same functions with SLC25A27. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
SLC25A27 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC25A27 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC25A27.
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