SLC25A19
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Official Full Name
solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 -
Overview
This gene encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. Mutations in this gene cause microcephaly, Amish type, a metabolic disease that results in severe congenital microcephaly, severe 2-ketoglutaric aciduria, and death within the first year. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. -
Synonyms
SLC25A19;solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19;mitochondrial thiamine pyrophosphate carrier;solute carrier family 25 member 19;solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19;DN
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Pongo Abelii
- Mus musculus
- Macaca fascicularis
- Bovine
- E.coli
- Mammalian Cell
- E.coli expression system
- In vitro E. coli expression system
- HEK293
- GST
- His
- His&GST
- His&Fc&Avi
Involved Pathway
SLC25A19 involved in several pathways and played different roles in them. We selected most pathways SLC25A19 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC25A19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SLC25A19 has several biochemical functions, for example, deoxynucleotide transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC25A19 itself. We selected most functions SLC25A19 had, and list some proteins which have the same functions with SLC25A19. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
SLC25A19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC25A19 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC25A19.
Cep152;ZWINT;CLTB;Cdk1;P;COX15;CHST15;HUWE1;Tubgcp5;FAM134A;Phospho1;GEMIN7;POLR3E;PCDHB15;Mad2l1
Resources
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References
- Nabokina, SM; Valle, JE; et al. Characterization of the human mitochondrial thiamine pyrophosphate transporter SLC25A19 minimal promoter: A role for NF-Y in regulating, basal transcription. GENE 528:248-255(2013).
