SLC25A12
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Official Full Name
solute carrier family 25 (aspartate/glutamate carrier), member 12 -
Overview
This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in the gene encoding this protein may be associated with risk of autism. -
Synonyms
SLC25A12;solute carrier family 25 (aspartate/glutamate carrier), member 12;solute carrier family 25 (mitochondrial carrier, Aralar), member 12;calcium-binding mitochondrial carrier protein Aralar1;Aralar;araceli hiperlarga;mitochondrial aspartate gl
Recombinant Proteins
- Zebrafish
- Mouse
- Rhesus macaque
- Human
- Pongo Abelii
- Mus musculus
- Mammalian Cell
- HEK293
- E.coli expression system
- Insect Cell
- E.coli
- His
- Non
- His&Flag&MBP
- His&T7
- His&Fc&Avi
Involved Pathway
SLC25A12 involved in several pathways and played different roles in them. We selected most pathways SLC25A12 participated on our site, such as Gluconeogenesis,Glucose metabolism,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC25A12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of carbohydrates | Gpc2,PFKLB,SLC35B2,SLC25A1,NHLRC1,HAS1,B3GNT2,PYGMB,UST,CHP |
| Glucose metabolism | GYG1B,EPM2A,NHLRC1,SLC25A13,GYG1A,PYGMB,SLC25A1,AGL,PFKLB,GYG1 |
| Metabolism of proteins | ADAMTS13,IGFBP5,MGAT4A,ADAMTS8,ARSJ,TIMM22,MUC21,GATA6,TIMM9,MAN1B1 |
| Gluconeogenesis | SLC25A10,GPR19,SLC25A11,SLC25A1,SLC25A1A,SLC25A13 |
| Metabolism | CSNK1G2,LBR,CHST9,NUDT16,DDAH1,Alb,CTH,ABHD14B,COX14,PDP1 |
| Mitochondrial protein import | TIMM21,FXC1,TIMM23,CHCHD4,TIMM17B,GRPEL1,TIMM13,TOMM20,TOMM6,SLC25A13 |
Protein Function
SLC25A12 has several biochemical functions, for example, L-aspartate transmembrane transporter activity,L-glutamate transmembrane transporter activity,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC25A12 itself. We selected most functions SLC25A12 had, and list some proteins which have the same functions with SLC25A12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| L-glutamate transmembrane transporter activity | SLC1A3,SLC17A8,SLC25A13,SLC17A6A,SLC1A6,SLC17A6,SLC1A2,SLC17A6B,SLC1A1,SLC38A7 |
| calcium ion binding | PLCH1,ATP2C1,ENPP2,PLCD1B,S100P,KCNIP3B,EGFL6,MYLPFA,CAPN3A,PCDH1G32 |
| L-aspartate transmembrane transporter activity | SLC1A6,SLC13A3,SLC38A7,SLC25A13 |
Interacting Protein
SLC25A12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC25A12 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC25A12.
JUND;SMAD3;PNKP;PELO;C20orf24;PHLDA3;fadE;ATG2A;Tpx2;15-deoxy-delta(12,14;MYC;PAEP;ATF2;AKAP5;HTT;Pafah1b1;ICT1;AATK;P
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References
- van Elst, LT; Maier, S; et al. Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: evidence in support of the excitatory/inhibitory imbalance hypothesis. MOLECULAR PSYCHIATRY 19:1314-1325(2014).
- Rueda, CB; Llorente-Folch, I; et al. Ca2+ regulation of mitochondrial function in neurons. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1837:1617-1624(2014).
