SLC22A3
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Official Full Name
solute carrier family 22 (organic cation transporter), member 3 -
Overview
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008] -
Synonyms
SLC22A3;solute carrier family 22 (organic cation transporter), member 3;EMT;EMTH;OCT3;solute carrier family 22 member 3;organic cation transporter 3;EMT organic cation transporter 3;extraneuronal monoamine transporter;solute carrier family 22 (extraneuronal monoamine transporter), member 3
Recombinant Proteins
- Human
- Rat
- Mus musculus
- Wheat Germ
- Mammalian Cell
- E.coli expression system
- HEK293
- Non
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC22A3-31412TH | Recombinant Human SLC22A3 | Wheat Germ | Human | Non | 66 amino acids |
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| SLC22A3-5457R | Recombinant Rat SLC22A3 Protein | Mammalian Cell | Rat | His |
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| RFL12585HF | Recombinant Full Length Human Solute Carrier Family 22 Member 3(Slc22A3) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-556) |
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| RFL23216RF | Recombinant Full Length Rat Solute Carrier Family 22 Member 3(Slc22A3) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length (1-551) |
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| RFL26026MF | Recombinant Full Length Mouse Solute Carrier Family 22 Member 3(Slc22A3) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-551) |
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| SLC22A3-5116R | Recombinant Rat SLC22A3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SLC22A3-5116R-B | Recombinant Rat SLC22A3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
SLC22A3 involved in several pathways and played different roles in them. We selected most pathways SLC22A3 participated on our site, such as Choline metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC22A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Choline metabolism in cancer | PIK3R2,MAP2K2,PRKCG,SLC22A1,PLA2G4C,RPS6KB2,SLC5A7,PDGFC,PDGFD,PDGFB |
Protein Function
SLC22A3 has several biochemical functions, for example, dopamine transmembrane transporter activity,organic cation transmembrane transporter activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC22A3 itself. We selected most functions SLC22A3 had, and list some proteins which have the same functions with SLC22A3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| quaternary ammonium group transmembrane transporter activity | SLC22A5,SLC22A1,SLC22A2 |
| toxin transporter activity | LRP6,SLC17A3,SLC7A8,SLC22A2,ABCG1 |
| protein binding | DYNC2LI1,LINGO1,SMYD2,STRAP,LRRC4B,ADAP2,TLE4,ROCK2A,ZSCAN16,SPATA7 |
| dopamine transmembrane transporter activity | SLC6A3,SLC22A1,SLC22A2 |
| organic cation transmembrane transporter activity | SLC22A14,SLC22A1,SLC22A2,SLC7A8 |
Interacting Protein
SLC22A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC22A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC22A3.
ABL1;NCK1
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References
- Shibbani, K; Fahed, AC; et al. Primary carnitine deficiency: novel mutations and insights into the cardiac phenotype. CLINICAL GENETICS 85:127-137(2014).
- Chu, SH; Zhou, ZM; et al. In vitro and in vivo radiosensitization of human glioma U251 cells induced by upregulated expression of SLC22A18. CANCER GENE THERAPY 21:103-109(2014).
