SLC22A1
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Official Full Name
solute carrier family 22 (organic cation transporter), member 1 -
Overview
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. -
Synonyms
SLC22A1;solute carrier family 22 (organic cation transporter), member 1;solute carrier family 22 member 1;OCT1;organic cation transporter 1;HOCT1;oct1_cds
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- His
- His&Fc&Avi
- Non
- GST
- N-His-SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC22A1-15261M | Recombinant Mouse SLC22A1 Protein | Mammalian Cell | Mouse | His |
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| SLC22A1-5451R | Recombinant Rat SLC22A1 Protein | Mammalian Cell | Rat | His |
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| SLC22A1-5110R | Recombinant Rat SLC22A1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SLC22A1-5110R-B | Recombinant Rat SLC22A1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SLC22A1-677H | Recombinant Human SLC22A1 Protein | Wheat Germ | Human | Non |
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| SLC22A1-6823HF | Recombinant Full Length Human SLC22A1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 1049 amino acids |
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| SLC22A1-8255M | Recombinant Mouse SLC22A1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SLC22A1-8255M-B | Recombinant Mouse SLC22A1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| SLC22A1-8544H | Recombinant Human SLC22A1 protein, His-SUMO-tagged | E.coli | Human | N-His-SUMO | 43-149aa |
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Involved Pathway
SLC22A1 involved in several pathways and played different roles in them. We selected most pathways SLC22A1 participated on our site, such as Bile secretion,Choline metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC22A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Choline metabolism in cancer | PDGFA,RAC1,PLD2,EIF4EBP1,MAPK10,SLC44A1,NRAS,Pdgfa&Pdgfb,SOS1,WASF3 |
| Bile secretion | SLC10A2,ATP1B1,ATP1A3,ATP1B2,NR1H4,AQP8,LDLR,NCEH1,CYP3A4,ABCG2 |
Protein Function
SLC22A1 has several biochemical functions, for example, acetylcholine transmembrane transporter activity,dopamine transmembrane transporter activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC22A1 itself. We selected most functions SLC22A1 had, and list some proteins which have the same functions with SLC22A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| monoamine transmembrane transporter activity | SLC18A2,SLC29A4,SLC18A1,SLC6A4,SLC6A2,SLC6A3 |
| identical protein binding | C10orf88,ZNF703,INHBA,MAP3K11,PSMD4,EDC3,ACPP,TLR3,PPPDE2,CLDND |
| organic cation transmembrane transporter activity | SLC7A8,SLC22A2,SLC22A14,SLC22A3 |
| transmembrane transporter activity | ATP5A1,SLC2A1A,ATP5O,SLC22A7B.1,SV2B,SLC22A17,ATP5C1,SLC2A13B,ATP5D,ATP5F1 |
| protein homodimerization activity | PEX7,GLIPR2,DROSHA,HOGA1,DMRT2,WRN,ZHX3,IKZF2,PRDM6,CTBP2 |
| dopamine transmembrane transporter activity | SLC22A2,SLC6A3,SLC22A3 |
| transporter activity | TIMM9,STEAP1,SLC15A4,CLVS2,RBP2,CPNE3,SLC4A1A,CRABP1A,CRABP2,PACSIN2 |
| quaternary ammonium group transmembrane transporter activity | SLC22A3,SLC22A5,SLC22A2 |
| norepinephrine transmembrane transporter activity | SLC6A2 |
Interacting Protein
SLC22A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC22A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC22A1.
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