SLC1A4
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Official Full Name
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -
Overview
SLC1A4, also known as ASCT1, is a neutral amino acid transporter. Its other name, ASCT1, was given because it mediates obligatory exchange of alanine, serine, cysteine, and threonine. SLC1A4 mediates the efflux of glutamate from the neuron into the synapt -
Synonyms
SLC1A4;solute carrier family 1 (glutamate/neutral amino acid transporter), member 4;neutral amino acid transporter A;solute carrier family 1 member 4;alanine/serine/cysteine/threonine transporter 1;SATT;ASCT1;ASCT-1;AW045657
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- E. coli
- Insect Cell
- Mammalian cells
- HEK293T
- His
- GST
- Non
- N-Twin strep and C-His&Flag
- His&Flag&MBP
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
SLC1A4 involved in several pathways and played different roles in them. We selected most pathways SLC1A4 participated on our site, such as Amino acid transport across the plasma membrane,SLC-mediated transmembrane transport,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC1A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SLC-mediated transmembrane transport | SLC16A1,SLC5A6A,SLC5A2,SLC6A20,SLC28A3,SLC20A2,SLC29A4,SLC5A3A,SLC9A8,SLC35D2 |
| Transport of inorganic cations/anions and amino acids/oligopeptides | SLC12A5B,SLC5A8,SLC15A1B,SLC12A7,SLC7A3,SLC6A18,SLC9A3.2,SLC4A3,SLC6A20,SLC7A6 |
| Amino acid transport across the plasma membrane | SLC6A20A,SLC43A2B,SLC38A3A,SLC6A12,SLC7A10,SLC6A19A,SLC7A6,SLC6A15,SLC36A2,SLC3A2A |
| Transmembrane transport of small molecules | SLC43A2B,GSDMA2,PDZD11,ATP11C,LCN1,SLC3A2B,SLC38A4,RHCG,AQP3B,ANO10 |
Protein Function
SLC1A4 has several biochemical functions, for example, L-alanine transmembrane transporter activity,L-cystine transmembrane transporter activity,NOT L-cystine transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC1A4 itself. We selected most functions SLC1A4 had, and list some proteins which have the same functions with SLC1A4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| L-proline transmembrane transporter activity | SLC36A4,SLC36A1,SLC36A3,SLC6A20A,SLC6A7,SLC36A2 |
| L-glutamine transmembrane transporter activity | SLC38A1,SLC1A5,SLC38A7,SLC38A3 |
| L-alanine transmembrane transporter activity | SLC36A1,SLC36A4,SLC36A2,SLC38A7,SLC38A3,SLC36A3 |
| sodium:dicarboxylate symporter activity | SLC1A7A,SLC1A6,SLC1A3B,SLC1A9,SLC1A2A,SLC1A2,SLC1A3A,SLC13A5A,SLC1A3,SLC1A2B |
| L-serine transmembrane transporter activity | SERINC1,SERINC4,SERINC3,SLC38A7,SLC7A10 |
| L-cystine transmembrane transporter activity | CTNS,SLC3A1 |
| chloride channel activity | CLCN3,GABRE,CLIC6,SLC26A3.2,SLC26A1,CLCA4,CLIC2,SLC26A2,GABRA1,GABRA5 |
Interacting Protein
SLC1A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC1A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC1A4.
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References
- Jiang, YX; Ma, Y; et al. Transcriptome and Coexpression Network Analysis of the Human Glioma Cell Line Hs683 Exposed to Candoxin. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 40:887-898(2012).
