SLC19A2
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Official Full Name
solute carrier family 19 (thiamine transporter), member 2 -
Overview
This gene encodes the thiamin transporter protein. Mutations in this gene cause thiamin-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness. -
Synonyms
SLC19A2;solute carrier family 19 (thiamine transporter), member 2;TRMA;thiamine transporter 1;THTR1;S19A2_HUMAN;Solute carrier family 19 member 2;TC1;Thiamine carrier 1;THT1;ThTr 1;ThTr-1;OTTHUMP00000033497;OTTHUMP00000033498;OTTHUMP00000033499;high affinity thiamine transporter;reduced folate carrier protein (RFC) like
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC19A2-4227R | Recombinant Rhesus monkey SLC19A2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| SLC19A2-1617HCL | Recombinant Human SLC19A2 cell lysate | Human | Non |
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| SLC19A2-0523H | Recombinant Human SLC19A2 Protein (D2-S497), 8×His-Strep, Flag tagged | Insect Cell | Human | His&Flag&Strep | D2-S497 |
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| SLC19A2-4043R | Recombinant Rhesus Macaque SLC19A2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SLC19A2-4043R-B | Recombinant Rhesus Macaque SLC19A2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| SLC19A2-4546H | Recombinant Human SLC19A2 protein, His&Myc-tagged | E.coli | Human | N-His&C-Myc | 215-293aa |
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Involved Pathway
SLC19A2 involved in several pathways and played different roles in them. We selected most pathways SLC19A2 participated on our site, such as Metabolism,Metabolism of vitamins and cofactors,Metabolism of water-soluble vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC19A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | TIAM2,SLC35B2,GPHNA,ADA,AKR1C21,CKMT1B,AFMID,NAT2,PDK3B,OAZ2B |
| Metabolism of vitamins and cofactors | KCNG4,SLC23A2,CTRB1,GSTO2,MOCOS,SLC5A6B,TCN1,GPHNA,ELA2L,SLC5A6A |
| Vitamin digestion and absorption | CUBN,BTD,APOA4,SLC19A1,MMACHC,LMBRD1,SLC5A6,GIF,LRAT,SLC19A3 |
| Metabolism of water-soluble vitamins and cofactors | SLC25A32,SLC2A3,SLC25A32A,SLC46A1,SLC25A32B,PDZD11,CTRC,CYB5A,CYB5R3,GPHNA |
Protein Function
SLC19A2 has several biochemical functions, for example, folic acid transporter activity,protein binding,thiamine transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC19A2 itself. We selected most functions SLC19A2 had, and list some proteins which have the same functions with SLC19A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | C1QTNF1,AXL,CTDNEP1,BAI2,CNNM3,CRLF3,NPM2,CHUK,GPSM1,ARNTL1A |
| thiamine uptake transmembrane transporter activity | C2orf83,SLC19A3B,SLC19A3 |
| folic acid transporter activity | FOLR2,FOLR1,SLC46A1,SLC19A1,SLC25A32,DAAM2 |
Interacting Protein
SLC19A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC19A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC19A2.
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