SLC17A7
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Official Full Name
solute carrier family 17 (vesicular glutamate transporter), member 7 -
Overview
The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008] -
Synonyms
SLC17A7;solute carrier family 17 (vesicular glutamate transporter), member 7;BNPI;VGLUT1;vesicular glutamate transporter 1;solute carrier family 17 member 7;brain-specific Na-dependent inorganic phosphate cotransporter;brain-specific Na(+)-dependent inorganic phosphate cotransporter;solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
Recombinant Proteins
- Mouse
- Rat
- Mammalian Cell
- Yeast
- HEK293
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC17A7-15246M | Recombinant Mouse SLC17A7 Protein | Mammalian Cell | Mouse | His |
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| SLC17A7-5442R | Recombinant Rat SLC17A7 Protein | Mammalian Cell | Rat | His |
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| Slc17a7-4543R | Recombinant Rat Slc17a7 protein, His-tagged | Yeast | Rat | His | 1-63aa |
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| SLC17A7-5101R | Recombinant Rat SLC17A7 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SLC17A7-5101R-B | Recombinant Rat SLC17A7 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SLC17A7-8244M | Recombinant Mouse SLC17A7 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SLC17A7-8244M-B | Recombinant Mouse SLC17A7 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SLC17A7 involved in several pathways and played different roles in them. We selected most pathways SLC17A7 participated on our site, such as Synaptic vesicle cycle,Retrograde endocannabinoid signaling,Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC17A7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Retrograde endocannabinoid signaling | GABRA1,ITPR3,GRIA4,PRKCB,PRKCA,FAAH,PRKCG,GNB1,GNG7,GABRE |
| Synaptic vesicle cycle | ATP6V0A4,SLC17A8,STX1A,SYT1,ATP6V1E2,STX2,CPLX4,CPLX3,ATP6V0D1,ATP6V1F |
| Glutamatergic synapse | SLC38A2,SLC38A1,GNG10,GRM7,GRIN3B,SLC1A3,PPP3CB,PRKACA,GNG11,GNB2 |
| Nicotine addiction | GRIN3A,CHRNA6,GRIN2B,GRIN3B,GABRR2,GABRR3,GABRA3,SLC17A6,GABRA5,GRIN1 |
Protein Function
SLC17A7 has several biochemical functions, for example, extracellular-glutamate-gated chloride channel activity,inorganic phosphate transmembrane transporter activity,sodium-dependent phosphate transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC17A7 itself. We selected most functions SLC17A7 had, and list some proteins which have the same functions with SLC17A7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sodium:inorganic phosphate symporter activity | SLC17A7A,SLC20A2,SLC20A1,SLC20A1A,SLC20A1B |
| sodium-dependent phosphate transmembrane transporter activity | SLC34A3,SLC34A2B,SLC17A3,SLC17A7A,SLC17A4,SLC34A2A,SLC34A2,SLC17A2,SLC17A1 |
| inorganic phosphate transmembrane transporter activity | SLC20A1,SLC20A1B,ANKH,SLC20A1A,SLC20A2 |
| symporter activity | SLC6A16B,SLC16A12,SLC5A12,SLC38A4,SLC34A3,SLC13A5,SLC1A3B,SLC6A6A,SLC5A8L,SLC16A1 |
Interacting Protein
SLC17A7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC17A7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC17A7.
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References
- Heyne, HO; Lautenschlager, S; et al. Genetic Influences on Brain Gene Expression in Rats Selected for Tameness and Aggression. GENETICS 198:1277-+(2014).
- Kim, JH; Kim, JH; et al. Chronic Sleep Deprivation-Induced Proteome Changes in Astrocytes of the Rat Hypothalamus. JOURNAL OF PROTEOME RESEARCH 13:4047-4061(2014).
