SLC13A3

  • Official Full Name

    solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

  • Overview

    Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.

  • Synonyms

    SLC13A3;solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3;solute carrier family 13 member 3;NADC3;SDCT2;+dicarboxylate cotransporter 3;H sapiens mRNA for hepatocyte nuclear factor 4 gamma;hNaDC3;Na;Na(+)/dicarboxylate cotransporter 3;NaDC 3;NaDC-3;S13A3_HUMAN;SDCT 2;Sodium dependent high affinity dicarboxylate transporter 2;Sodium-dependent high-affinity dicarboxylate transporter 2;OTTHUMP00000031667;OTTHUMP00000214796;OTTHUMP00000214797;OTTHUMP00000214798;sodium-dependent high affinity dicarboxylate transporter 3;sodium-dependent high-affinity dicar
Cat.# Product name Source (Host) Species Tag Protein Length Price
SLC13A3-12157Z Recombinant Zebrafish SLC13A3 Mammalian Cell Zebrafish His
SLC13A3-1615HCL Recombinant Human SLC13A3 cell lysate Human Non
SLC13A3-301259H Recombinant Human SLC13A3 protein, GST-tagged E.coli Human GST Ser161-Asn229
SLC13A3-301399H Recombinant Human SLC13A3 protein, GST-tagged E.coli Human GST Gln568-Leu602
SLC13A3-672H Recombinant Human SLC13A3 Protein, GST-tagged Wheat Germ Human GST 1-602 aa
SLC13A3-6818HF Recombinant Full Length Human SLC13A3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 602 amino acids

    Involved Pathway

    SLC13A3 involved in several pathways and played different roles in them. We selected most pathways SLC13A3 participated on our site, such as SLC-mediated transmembrane transport,Sodium-coupled sulphate, di- and tri-carboxylate transporters,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC13A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    SLC-mediated transmembrane transport LCN15,SLC22A16,SLC38A3,SLC7A8A,SLC39A8,SLC31A1,SLC30A8,SLC6A1A,SLC5A6B,SLC1A3B
    Transmembrane transport of small molecules TRPC4APB,SLC13A4,SLC34A3,SLC31A1,SLC2A13,ABCC2,SLC13A1,SLC1A3B,Ano3,SLC8A2A
    Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A5,SLC13A5A,SLC13A4,SLC13A2,SLC13A1
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds SLC41A1,SLC6A7,SLC6A20,SLC44A5B,RHCGL1,SLC39A10,SLC39A7,SLC22A16,SLC6A6A,SLC13A4

    Protein Function

    SLC13A3 has several biochemical functions, for example, L-aspartate transmembrane transporter activity,citrate transmembrane transporter activity,high-affinity sodium:dicarboxylate symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC13A3 itself. We selected most functions SLC13A3 had, and list some proteins which have the same functions with SLC13A3. You can find most of the proteins on our site.

    Function Related Protein
    succinate transmembrane transporter activity SLC13A5A,SLC13A5
    citrate transmembrane transporter activity SLC25A1,SLC13A5A,SFXN5,SLC13A5
    L-aspartate transmembrane transporter activity SLC25A13,SLC38A7,SLC25A12,SLC1A6
    sodium:dicarboxylate symporter activity SLC1A2A,SLC13A5,SLC1A3B,SLC1A3A,SLC13A5A,SLC1A2B,SLC1A2,SLC1A3,SLC1A7,SLC1A1

    Interacting Protein

    SLC13A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC13A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC13A3.

    Resources

    Research Area

    Renal Markers
    Glial Lineage Markers

    References

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