SLC12A1
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Official Full Name
solute carrier family 12 (sodium/potassium/chloride transporter), member 1 -
Overview
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henles loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010] -
Synonyms
SLC12A1;solute carrier family 12 (sodium/potassium/chloride transporter), member 1;BSC1;NKCC2;solute carrier family 12 member 1;NKCC2A variant A;Na-K-2Cl cotransporter;kidney-specific Na-K-Cl symporter;bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2;solute carrier family 12 (sodium/potassium/chloride transporters), member 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC12A1-2697H | Recombinant Human SLC12A1, His-tagged | E.coli | Human | His | 1-176aa | |
| SLC12A1-1202H | Recombinant Human SLC12A1 protein, His & T7-tagged | E.coli | Human | His&T7 | Arg814~Ser1099 |
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| SLC12A1-15207M | Recombinant Mouse SLC12A1 Protein | Mammalian Cell | Mouse | His |
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| SLC12A1-31410TH | Recombinant Human SLC12A1 | Wheat Germ | Human | Non | 93 amino acids |
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| SLC12A1-8216M | Recombinant Mouse SLC12A1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SLC12A1-8216M-B | Recombinant Mouse SLC12A1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SLC12A1 involved in several pathways and played different roles in them. We selected most pathways SLC12A1 participated on our site, such as Cation-coupled Chloride cotransporters,SLC-mediated transmembrane transport,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC12A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cation-coupled Chloride cotransporters | SLC12A7,SLC12A5B,SLC12A4,SLC12A3 |
| SLC-mediated transmembrane transport | SLC12A7,SLC30A1A,SLC24A4A,SLC47A1,SLC26A7,SLC1A3A,SLC13A5,SLC2A15A,SLC43A1B,SLC6A5 |
| Transport of inorganic cations/anions and amino acids/oligopeptides | SLC38A3,SLC6A20B,SLC15A1B,SLC9A7,SLC17A1,SLC7A6,SLC24A5,SLC7A10,SLC26A6L,SLC9A5 |
| Transmembrane transport of small molecules | ABCE1,RHAG,SLC7A6,NHEDC1,AZGP1,ATP13A5,SLC5A9,AQP10B,Ano3,SLC9A10 |
Protein Function
SLC12A1 has several biochemical functions, for example, potassium ion symporter activity,potassium:chloride symporter activity,sodium ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC12A1 itself. We selected most functions SLC12A1 had, and list some proteins which have the same functions with SLC12A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sodium ion transmembrane transporter activity | ASIC4,SLC23A1,SLC12A10.1,TRAPPC10,SLC12A10.3,SLC12A3,CNNM4,SLC12A10.2 |
| sodium:chloride symporter activity | SLC12A10.2,SLC12A3,SLC12A10.1,SLC12A10.3 |
| potassium:chloride symporter activity | SLC12A10.2,SLC12A5B,SLC12A7,SLC12A10.3,SLC12A5,SLC12A2,SLC12A4,SLC12A8,SLC12A10.1 |
| potassium ion symporter activity | SLC12A10.3,SLC12A8,SLC12A10.2,SLC12A4,SLC12A2,SLC12A5B,SLC12A7,SLC12A5,SLC12A10.1 |
| sodium:potassium:chloride symporter activity | SLC12A10.1,SLC12A10.3,SLC12A10.2 |
Interacting Protein
SLC12A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC12A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC12A1.
pta;Oxsr1;Stk39
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References
- Rasmussen, LJH; Muller, HSH; et al. Osmotic shrinkage elicits FAK- and Src phosphorylation and Src-dependent NKCC1 activation in NIH3T3 cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 308:C101-C110(2015).
- Castrop, H; Schiessl, IM; et al. Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2). AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 307:F991-F1002(2014).
