SLAMF1
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Official Full Name
signaling lymphocytic activation molecule family member 1 -
Overview
CD150, designated SLAM (Signaling Lymphocyte Activation Molecule) or CDw150, belongs to the immunoglobulin gene superfamily and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form, the soluble form and the cytoplasmic isoforms of SLAM. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells. -
Synonyms
SLAMF1;signaling lymphocytic activation molecule family member 1;signaling lymphocytic activation molecule;signaling lymphocyte activation molecule;Slam;CD150;IPO-3;CDw150;ESTM51;AA177906;4933415F16;MGC151472;MGC151476
Recombinant Proteins
- Human
- Rat
- Rhesus macaque
- Mouse
- HEK293
- Human Cell
- E.coli
- Mammalian cells
- His
- His&Avi
- Fc
- Non
- hIgG4
- His&T7
- His&mFc
Involved Pathway
SLAMF1 involved in several pathways and played different roles in them. We selected most pathways SLAMF1 participated on our site, such as Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLAMF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Measles | IKBKE,NFKB1,IFNA6,PIK3CA,IFIH1,IRAK4,HSPA1B,FYN,IL13,NFKBIA |
Protein Function
SLAMF1 has several biochemical functions, for example, antigen binding,protein binding,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLAMF1 itself. We selected most functions SLAMF1 had, and list some proteins which have the same functions with SLAMF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| virus receptor activity | CCR5,ITGB5,CR1,CD86,CD46,ITGB7,HAVCR1,SERPINB3,CLEC5A,LAMP1 |
| antigen binding | IGKV1-5,IGHM,LCK,PPP2R1A,MHC1UKA,KIR2DL3,Ighg2a,IGLC2,FCN2,Ighg |
| transmembrane signaling receptor activity | IGSF6,BAI2,TLR2-2,ERBB2,EBP,IL1R1,GPR98,FCGR2C,TLR5,IL4R.1 |
| protein binding | FAH,RNF32,ATP6V1F,INPP5D,REXO1L1,ZNF177,DCBLD2,RUFY3,FAM134B,PPP5C |
Interacting Protein
SLAMF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLAMF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLAMF1.
SH2D1A;H;PTPN11;INPP5D
Resources
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References
- van Driel, B; Liao, GX; et al. Signaling Lymphocyte Activation Molecule Regulates Development of Colitis in Mice. GASTROENTEROLOGY 143:1544-+(2012).
- Calderon, J; Maganto-Garcia, E; et al. The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi. PLOS PATHOGENS 8:-(2012).
