SKIL

  • Official Full Name

    SKI-like oncogene

  • Overview

    The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.

  • Synonyms

    SKIL;SKI-like oncogene;ski-like protein;SNO;SnoA;SnoN;ski-related oncogene snoN;SnoI
Cat.# Product name Source (Host) Species Tag Protein Length Price
SKIL-2688H Recombinant Human SKIL, His-tagged E.coli Human His 335-684aa
SKIL-27723TH Recombinant Human SKIL Wheat Germ Human Non 684 amino acids
SKIL-27724TH Recombinant Human SKIL Wheat Germ Human Non 78 amino acids
SKIL-6729C Recombinant Chicken SKIL Mammalian Cell Chicken His
SKIL-1814HCL Recombinant Human SKIL 293 Cell Lysate HEK293 Human Non
SKIL-478HF Recombinant Full Length Human SKIL Protein In Vitro Cell Free System Human Full L. 684 amino acids

    Involved Pathway

    SKIL involved in several pathways and played different roles in them. We selected most pathways SKIL participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SKIL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling pathways regulating pluripotency of stem cells FZD6,PIK3R1,DLX5,ACVR2B,WNT2B,SMAD3,WNT10B,WNT9B,PIK3CB,MAPK13

    Protein Function

    SKIL has several biochemical functions, for example, NOT DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SKIL itself. We selected most functions SKIL had, and list some proteins which have the same functions with SKIL. You can find most of the proteins on our site.

    Function Related Protein
    NOT DNA binding MBD5,HIPK2,NFIB,XRCC4,TINF2
    transcription corepressor activity TGIF1,HSBP1,LHX1,NFKBIL2,ZFPM2,CREG1,TLE4,TDP2,JUB,AEBP2
    protein domain specific binding VPS11,YWHAZ,WNT3,ERCC1,YWHAG1,ARRB2,MTOR,RAB27A,NFE2L2,ZFP521
    protein binding MAF,EMD,ASL,GEMIN4,ATP6V1C1,CDK1,CYBB,C22orf13,PLXND1,KCNH7
    chromatin binding SOX9A,SHMT2,TP53,YBX2,PDX1,PRKCBP1L,ATXN7,EP300,NAP1L2,TP73
    SMAD binding SKOR1B,RNF111,TGFBR2,SKILB,SMURF2,PRDM16,SKOR1A,TCF12,HIPK2,ACVR1B
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RELA,SPI1,CC2D1B,HHEX,SP3,NACC2,NKX6-2,PROX1A,NFIL3-4,RCOR1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding KLF5,MYF5,PHOX2B,ZNF257,HOXA5,ZNF718,HOXC11,ATOH1,MAFB,MLXIPL
    protein complex binding LRP1,NRAS,TAB1,GNB1,CFLAR,SLC25A3,CDK4,KAT2B,Cel,KRIT1

    Interacting Protein

    SKIL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SKIL here. Most of them are supplied by our site. Hope this information will be useful for your research of SKIL.

    OIP5;STK16;AES;VPS28;NXF3;DRG1;Ncor1

    Resources

    References

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All SKIL Products

    Required fields are marked with *

    My Review for All SKIL Products

    Required fields are marked with *