SIRT7
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Official Full Name
sirtuin 7 -
Overview
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. -
Synonyms
SIRT7;sirtuin 7;sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7;NAD-dependent deacetylase sirtuin-7;sirtuin type 7;SIR2-like protein 7
Recombinant Proteins
- Human
- Rat
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- HEK293T
- Mammalian cells
- His
- Flag
- T7
- Non
- His&Fc&Avi
- His&Myc
- Myc&DDK
Involved Pathway
SIRT7 involved in several pathways and played different roles in them. We selected most pathways SIRT7 participated on our site, such as Signaling events mediated by HDAC Class I,Signaling events mediated by HDAC Class III, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling events mediated by HDAC Class III | SIRT2 |
| Signaling events mediated by HDAC Class I | TFCP2,WDR77,FKBP3,SIRT2,PRMT5,NR2C1,GATA2,SIRT5,MXD1,SIRT4 |
Protein Function
SIRT7 has several biochemical functions, for example, NAD+ binding,NAD-dependent histone deacetylase activity (H3-K18 specific),chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT7 itself. We selected most functions SIRT7 had, and list some proteins which have the same functions with SIRT7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD+ binding | SIRT6,HPGD,SIRT4,SIRT5,HADH,ALDH1A3,SIRT2,SIRT1,UXS1,GLUD1 |
| chromatin binding | FEZF2,LOXL2,RNF168,PCNA,TSHZ3,ENY2,RUNX2,EGFR,PLAC8,SSRP1A |
| protein binding | CABP5,CASP10,ZFPM2A,NDFIP2,NOP10,HRASLS5,TLN1,PPP4R4,MAGOH,F11 |
| metal ion binding | NRP1,NR2F1B,COL27A1,ABAT,UPB1,ZFP593,EXT1,POLL,SMYD4,GTPBP6 |
Interacting Protein
SIRT7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT7.
MAGED1;CBX1
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References
- Kiran, S; Chatterjee, N; et al. Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal. FEBS JOURNAL 280:3451-3466(2013).
