SIGLEC11
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Official Full Name
sialic acid binding Ig-like lectin 11 -
Overview
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SIGLEC11;sialic acid binding Ig-like lectin 11;sialic acid-binding Ig-like lectin 11;siglec-11
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SIGLEC11-376H |
Active Recombinant Human SIGLEC11, Fc Chimera
|
CHO | Human | Fc |
|
|
| SIGLEC11-1848HCL | Recombinant Human SIGLEC11 293 Cell Lysate | HEK293 | Human | Non |
|
Involved Pathway
SIGLEC11 involved in several pathways and played different roles in them. We selected most pathways SIGLEC11 participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIGLEC11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | SIGLEC10,Siglece,Mill2,KIR2DS2,SIGLEC6,CLEC2B,CLEC2G,SIGLEC7,CD300LF,CD300A |
| Immune System | CISH,CLEC5A,DEFB125,NA,CASP4,GBP2,ARIH1L,MYO1C,ASB8,MYO9B |
| Adaptive Immune System | FGF18B,PIK3AP1,DCTN1,CXADR,CD200,RNF6,KIF18A,ERAP1,AP1M2,UBE2L6 |
Protein Function
SIGLEC11 has several biochemical functions, for example, carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIGLEC11 itself. We selected most functions SIGLEC11 had, and list some proteins which have the same functions with SIGLEC11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | CLEC18B,KLRC1,Reg2,FCER2,Cd209g,CANX,DGCR2,LGALS2,CLEC4D,CALR3 |
Interacting Protein
SIGLEC11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIGLEC11 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIGLEC11.
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References
- Wang, XX; Chow, R; et al. Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology. GLYCOBIOLOGY 21:1038-1048(2011).
- Varki, A; et al. Uniquely human evolution of sialic acid genetics and biology. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107:8939-8946(2010).
