SIAH1

  • Official Full Name

    seven in absentia homolog 1 (Drosophila)

  • Overview

    This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinsons disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

  • Synonyms

    SIAH1;seven in absentia homolog 1 (Drosophila);E3 ubiquitin-protein ligase SIAH1;hSIAH1;HUMSIAH;Seven in absentia homolog 1;SIAH 1;Siah 1a;Ubiquitin ligase SIAH1;siah-1a;OTTHUMP00000164188;OTTHUMP00000164189;SIAH1A

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • HEK293
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SIAH1-2668H Recombinant Human SIAH1, GST-tagged E.coli Human GST 1-282aa
SIAH1-4200R Recombinant Rhesus monkey SIAH1 Protein, His-tagged Mammalian Cell Rhesus macaque His
SIAH1-9929Z Recombinant Zebrafish SIAH1 Mammalian Cell Zebrafish His
SIAH1-1851HCL Recombinant Human SIAH1 293 Cell Lysate HEK293 Human Non
SIAH1-4016R Recombinant Rhesus Macaque SIAH1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
SIAH1-4016R-B Recombinant Rhesus Macaque SIAH1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
SIAH1-4629H Recombinant Human SIAH1 protein, GST-tagged E.coli Human GST 1-313aa

    Involved Pathway

    SIAH1 involved in several pathways and played different roles in them. We selected most pathways SIAH1 participated on our site, such as p signaling pathway,Ubiquitin mediated proteolysis,Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIAH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    p signaling pathway SESN2,RFWD2,TP53I3,TRP53,PERP,PTENB,Casp3,CASP9,CCND1,SFN
    Wnt signaling pathway WNT1,FRAT2,PRKCG,NKD2B,FZD8A,WNT11R,Fzd4,FZD3,PRKACB,PPP3CCA
    Ubiquitin mediated proteolysis WWP2,UBE2IB,TCEB2,UBE2G1A,ANAPC5,UBE2NB,UBE2E1,CUL4B,MGRN1A,HUWE1

    Protein Function

    SIAH1 has several biochemical functions, for example, identical protein binding,ligase activity,protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIAH1 itself. We selected most functions SIAH1 had, and list some proteins which have the same functions with SIAH1. You can find most of the proteins on our site.

    Function Related Protein
    protein C-terminus binding SNF8,FBLN1,SLC4A1,PIAS3,TAX1BP3,DGKZ,KSR1,ZBTB16,CDC20,SAE1
    zinc ion binding CHURC1,LIMCH1A,QPCTL,MARCH5,RNF41,RFPL2,HNF4G,ZCCHC18,EDEM3,RNF26
    ubiquitin-protein transferase activity LNX1,UBE2D2A,UBE2M,PEX12,MIB1,UBE2H,NSMCE1,ITCH,UBE2E1,WDSUB1
    ubiquitin protein ligase activity G2E3,PDZRN3B,ARIH1L,RNF149,RNF144AA,UBE2S,UBE2C,ZNRF2,TRIM3,RABGEF1
    identical protein binding NONO,HAPLN2,TRAF6,ATL1,KCTD17,LYZ,IAPP,DLC,S100A4,CBS
    protein binding AGO3,C1orf50,NDFIP2,INCENP,ADCK5,KLB,ALDOB,REXO1L1,GBP1,GFM1
    ligase activity RFWD3,CMTM2A,GLULB,TRIP12,TRAF3,CBL,TRIM21,DTX1,RBCK1,PPIL2

    Interacting Protein

    SIAH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIAH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIAH1.

    PHC2;PUF60;EEF1D;UBE2K

    Resources

    Research Area

    Notch Pathway

    References

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