SH2B2
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Official Full Name
SH2B adaptor protein 2 -
Overview
APS is an SH2 and PH domain-containing adaptor protein closely related to Lnk and SH2-B. APS was identified as a substrate for many receptor tyrosine kinases including TrkA, insulin receptor, c-Kit and PDGF receptor. Tyrosine phosphorylation of APS provid -
Synonyms
SH2B2;SH2B adaptor protein 2;SH2B adapter protein 2;adaptor protein with pleckstrin homology and src;APS;SH2 and PH domain-containing adapter protein APS;adapter protein with pleckstrin homology and Src homology 2 domains;adaptor protein with pleck
Recombinant Proteins
- Human
- Mouse
- Guinea pig
- Rat
- Wheat Germ
- Mammalian Cell
- E.Coli or Yeast
- HEK293
- HEK293T
- GST
- His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| APS-730H | Recombinant Human APS protein, GST-tagged | Wheat Germ | Human | GST |
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| SH2B2-15052M | Recombinant Mouse SH2B2 Protein | Mammalian Cell | Mouse | His |
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| Sh2b2-3307C | Recombinant Cavia porcellus (Guinea pig) Sh2b2, His-tagged | E.Coli or Yeast | Guinea pig | His | 405 |
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| SH2B2-5372R | Recombinant Rat SH2B2 Protein | Mammalian Cell | Rat | His |
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| SH2B2-1341H | Recombinant Human SH2B2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| SH2B2-5031R | Recombinant Rat SH2B2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SH2B2-5031R-B | Recombinant Rat SH2B2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Sh2b2-5833M | Recombinant Mouse Sh2b2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| SH2B2-8114M | Recombinant Mouse SH2B2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SH2B2-8114M-B | Recombinant Mouse SH2B2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SH2B2 involved in several pathways and played different roles in them. We selected most pathways SH2B2 participated on our site, such as Neurotrophin signaling pathway,Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH2B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin signaling pathway | HK3,EIF4E2RS1,CALM2B,PCK1,CALML5,PRKACAB,MKNK2B,PRKAB1,PRKAR2AA,SOCS1A |
| Neurotrophin signaling pathway | CALM1,CAMK2A,AKT1,PLCG2,SORT1,SHC1,SHC3,CAMK2B,PIK3CG,NTF4 |
Protein Function
SH2B2 has several biochemical functions, for example, JAK pathway signal transduction adaptor activity,SH3/SH2 adaptor activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SH2B2 itself. We selected most functions SH2B2 had, and list some proteins which have the same functions with SH2B2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3/SH2 adaptor activity | SLA2,GRB10,NCK1,NCK2,PTPN11,SH3BP2,GRB7,ARHGAP4,SH2D3A,SH2D1A |
| protein binding | ECD,TMEM41A,ZBTB17,AGTR2,STIM1,RSPH3,USH1C,CREBZF,MPP1,DUSP7 |
| transmembrane receptor protein tyrosine kinase adaptor activity | IRS1,SHC1,FRS2,GAB2,PIK3R1,TRAT1,DOK2,BLNK,STAP1 |
| signaling adaptor activity | AFAP1L2,MPP7,GNB2L1,LDLRAP1,SH2B3,HOMER1,SH2B1 |
| identical protein binding | RNF4,YWHAZ,HGF,VPS4B,MSANTD3,MDM2,Serpina1c,GPSM2,INS,SNX33 |
| signal transducer activity | TAAR7B,RGS9B,RHOC,HTR1D,GHRHRA,TAAR8B,SLC35B2,GPR34L,TAS2R116,OLFR24 |
| JAK pathway signal transduction adaptor activity | SOCS2 |
Interacting Protein
SH2B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH2B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SH2B2.
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References
- Perez-Garcia, A; Ambesi-Impiombato, A; et al. Genetic loss of SH2B3 in acute lymphoblastic leukemia. BLOOD 122:2425-2432(2013).
- de Boer, YS; van Gerven, NMF; et al. Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1. GASTROENTEROLOGY 147:443-+(2014).
