SGCG
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Official Full Name
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -
Overview
This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). -
Synonyms
SGCG;sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein);DMDA1, LGMD2C, MAM, sarcoglycan, gamma (35kD dystrophin associated glycoprotein);gamma-sarcoglycan;35kD dystrophin associated glycoprotein;A4;DAGA4;DMDA;gamma sarcoglycan;limb girdle muscular dystrophy 2C (Duchenne like muscular dystrophy;autosomal recessive);Maghrebian myopathy (autosomal recessive);MGC130048;SCARMD2;SCG3;TYPE;35 kDa dystrophin associated glycoprotein;Gamma SG;35 kDa dystrophin-associated glycoprotein;35DAG;DMDA1;Gamma-SG;LGMD2C;MAM;Sarcoglycan gamma;SGCG_HUMAN;OTTHUMP00000018112;35kD dystrophin-associated glycoprotein
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Mesocricetus auratus
- Mus musculus
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli expression system
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SGCG-2629H | Recombinant Human SGCG, His-tagged | E.coli | Human | His | 1-291aa | |
| SGCG-1087Z | Recombinant Zebrafish SGCG | Mammalian Cell | Zebrafish | His |
|
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| SGCG-15032M | Recombinant Mouse SGCG Protein | Mammalian Cell | Mouse | His |
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| SGCG-26403TH | Recombinant Human SGCG | Wheat Germ | Human | Non | 100 amino acids |
|
| SGCG-28970TH | Recombinant Human SGCG | Wheat Germ | Human | Non | 291 amino acids |
|
| SGCG-1887HCL | Recombinant Human SGCG 293 Cell Lysate | HEK293 | Human | Non |
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| RFL14882MF | Recombinant Full Length Mesocricetus Auratus Gamma-Sarcoglycan(Sgcg) Protein, His-Tagged | E.coli expression system | Mesocricetus auratus | His | Full L. Full Length (1-291) |
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| RFL29667MF | Recombinant Full Length Mouse Gamma-Sarcoglycan(Sgcg) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-291) |
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| SGCG-1905HFL | Recombinant Full Length Human SGCG Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| SGCG-1996H | Recombinant Human SGCG Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| SGCG-1996H-B | Recombinant Human SGCG Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| SGCG-359H | Recombinant Human SGCG Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| SGCG-469HF | Recombinant Full Length Human SGCG Protein | In Vitro Cell Free System | Human | Full L. 291 amino acids |
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| Sgcg-5822M | Recombinant Mouse Sgcg Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| SGCG-8099M | Recombinant Mouse SGCG Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SGCG-8099M-B | Recombinant Mouse SGCG Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SGCG involved in several pathways and played different roles in them. We selected most pathways SGCG participated on our site, such as Hypertrophic cardiomyopathy (HCM),Arrhythmogenic right ventricular cardiomyopathy (ARVC),Dilated cardiomyopathy, which may be useful for your reference. Also, other proteins which involved in the same pathway with SGCG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypertrophic cardiomyopathy (HCM) | ITGB8,TNNC1,PRKAG2,IL6,TNF,ITGA9,ITGB6,CACNG7,ITGA6,PRKAB2 |
| Viral myocarditis | SGCD,CASP8,ACTG1,HLA-DQB1,CYCS,HLA-DPA1,HLA-DRA,HLA-E,H2-AB1,EIF4G2 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGA3,DSP,SGCB,SGCA,CACNB4,ITGA6,Itga10&Itgb1,TCF7L2,CACNA2D4,CACNG7 |
| Dilated cardiomyopathy | TNNI3,CACNA2D3,ITGA7,ITGB7,ITGA2B,ITGB1,PRKACB,RYR2,DES,ITGB6 |
Protein Function
SGCG has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SGCG itself. We selected most functions SGCG had, and list some proteins which have the same functions with SGCG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | HTN1,CHDH,CTAG2,CLDN16,HPN,LUZP4,NPDC1,TSHZ3,CXXC5,SCNN1G |
Interacting Protein
SGCG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SGCG here. Most of them are supplied by our site. Hope this information will be useful for your research of SGCG.
FLNC;DNAJB6;DYSF;ACO1;PTPN11;ENO1;PSAP;HSPA1A;PYGM;ENO3;CCT6A;MYBPC1;MYBPC2
Resources
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References
- Goldstein, JA; Bogdanovich, S; et al. Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy. HUMAN MOLECULAR GENETICS 23:6722-6731(2014).
- Boulay, AC; Saubamea, B; et al. The Sarcoglycan complex is expressed in the cerebrovascular system and is specifically regulated by astroglial Cx30 channels. FRONTIERS IN CELLULAR NEUROSCIENCE 9:-(2015).
